Ginestier Christophe, Korkaya Hasan, Dontu Gabriela, Birnbaum Daniel, Wicha Max S, Charafe-Jauffret Emmanuelle
University of Michigan Medical Center, Comprehensive Cancer Center, Int Med-Hematology/Oncology, 1500 E Medical Center Drive, Ann Arbor, MI, USA.
Med Sci (Paris). 2007 Dec;23(12):1133-9. doi: 10.1051/medsci/200723121133.
Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/low lin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.
近期对包括乳腺癌在内的多种肿瘤的研究支持了“癌症干细胞假说”。基于此，肿瘤包含一个保留关键干细胞特性的细胞亚群并由其驱动。这些特性包括驱动肿瘤发生的自我更新能力以及产生细胞异质性的能力。最近，人们使用了不同技术来分离具有细胞表面表型CD44+CD24-/低lin-或表达乙醛脱氢酶的潜在乳腺癌干细胞。该模型对乳腺癌治疗具有重要意义。开发针对这一细胞群的特异性疗法是未来的一个重要研究重点。
