Song Gengqing, Hou Xiaohua, Yang Bin, Liu Jinsong, Qian Wei, Chen Jiande D Z
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Dig Dis Sci. 2005 Apr;50(4):662-8. doi: 10.1007/s10620-005-2553-5.
The aim of this study was to investigate the effects of two-channel gastric electrical stimulation (GES) on delayed gastric emptying, gastric dysrhythmias, and motion sickness-like symptoms induced by vasopressin. Seven dogs implanted with four pairs of gastric electrodes and a duodenal cannula were studied in four randomized sessions (saline, vasopressin, single-channel GES, and two-channel GES). The experiment in each session was conducted sequentially as follows: 30-min baseline, ingestion of a liquid meal, 30-min iv infusion of vasopressin or saline, and two 30-min postprandial recordings. In the GES sessions, GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for two-channel GES. Gastric emptying was collected every 15 min via the cannula for a period of 90 min. Results were as follows. (1) Vasopressin induced gastric dysrhythmias, motion sickness-like symptoms, and delayed gastric emptying (P < 0.01, ANOVA). (2) GES normalized gastric dysrhythmias (P < 0.01) but showed no effects on vasopressin-induced emetic response. (3) Two-channel GES improved delayed gastric emptying induced by vasopressin. In comparison with the vasopressin session, two-channel GES, but not single-channel GES, significantly increased gastric emptying at 30 min (43.9+/-12.6 vs. 27.5+/-7.7%; P < 0.03), 60 min (75.3+/-15.1 vs. 54.0+/-17.8%; P < 0.05), and 90 min (91.6+/-9.8 vs. 80.3+/-9.0%; P < 0.05). GES with long pulses is able to normalize gastric dysrhythmias. Two-channel GES improves delayed gastric emptying induced by vasopressin.
本研究旨在探讨双通道胃电刺激（GES）对血管加压素诱导的胃排空延迟、胃节律紊乱和晕动病样症状的影响。对7只植入了四对胃电极和十二指肠插管的犬进行了四个随机阶段的研究（生理盐水、血管加压素、单通道GES和双通道GES）。每个阶段的实验按以下顺序进行：30分钟基线期、摄入流质餐、30分钟静脉输注血管加压素或生理盐水，以及两个30分钟的餐后记录期。在GES阶段，通过第一对电极进行单通道GES，或通过第一对和第三对电极进行双通道GES。通过插管每15分钟收集一次胃排空情况，持续90分钟。结果如下：（1）血管加压素诱导胃节律紊乱、晕动病样症状和胃排空延迟（方差分析，P<0.01）。（2）GES使胃节律紊乱恢复正常（P<0.01），但对血管加压素诱导的呕吐反应无影响。（3）双通道GES改善了血管加压素诱导的胃排空延迟。与血管加压素阶段相比，双通道GES而非单通道GES在30分钟时显著增加胃排空（43.9±12.6%对27.5±7.7%；P<0.03），60分钟时（75.3±15.1%对54.0±17.8%；P<0.05），以及90分钟时（91.6±9.8%对80.3±9.0%；P<0.05）。长脉冲GES能够使胃节律紊乱恢复正常。双通道GES改善了血管加压素诱导的胃排空延迟。
