Sobti Ranbir Chander, Kordi Tamandani Dor Mohammad, Shekari Mohammad, Kaur Pushpinder, Malekzadeh Keyanoosh, Suri Vanita
Department of Biotechnology, Panjab University, Chandigarh, India.
Int J Gynaecol Obstet. 2008 Apr;101(1):47-52. doi: 10.1016/j.ijgo.2007.10.014. Epub 2007 Dec 21.
To determine whether a polymorphism at position +3953 in exon 5 of the lL-1beta gene (IL-1beta +3953), a condition associated with an increased risk for a number of inflammatory diseases, is also involved in the development of cervical cancer.
We isolated DNA from peripheral blood in 150 women with cervical cancer and 200 healthy controls, and IL-1beta +3953 allele polymorphism was determined by polymerase chain reaction.
Genotypes A1/A2 and A2/A2+A1/A2 were associated with increased risk of cervical cancer (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.78-4.67; P<0.001 and OR, 2.85; 95% CI, 1.77-4.6; P<0.001, respectively). The risk in a passive smoker with A2/A2 or A1/A2 genotype was increased more than 5-fold (OR, 5.69; 95% CI, 2.61-12.50; P<0.001) compared with a nonsmoker with the A1/A1 genotype.
This study provides evidence of an association between lL-1beta +3953 polymorphism and risk of cervical cancer.
确定白细胞介素-1β基因（IL-1β）第5外显子+3953位的多态性，这种情况与多种炎症性疾病风险增加相关，是否也参与宫颈癌的发生发展。
我们从150例宫颈癌女性患者和200例健康对照者的外周血中提取DNA，采用聚合酶链反应测定IL-1β +3953等位基因多态性。
基因型A1/A2和A2/A2+A1/A2与宫颈癌风险增加相关（优势比[OR]分别为2.88；95%置信区间[CI]为1.78 - 4.67；P<0.001和OR为2.85；95%CI为1.77 - 4.6；P<0.001）。与A1/A1基因型的非吸烟者相比，A2/A2或A1/A2基因型的被动吸烟者风险增加超过5倍（OR为5.69；95%CI为2.61 - 12.50；P<0.001）。
本研究提供了IL-1β +3953多态性与宫颈癌风险之间存在关联的证据。
