Pollicino P, Rossi L, Rambozzi L, Farca A M, Peano A
Dipartimento di Patologia Animale, Via Leonardo da Vinci 44, 10095 Grugliasco (TO), Italy.
Vet Parasitol. 2008 Feb 14;151(2-4):355-7. doi: 10.1016/j.vetpar.2007.10.018. Epub 2007 Nov 4.
A field trial was conducted to assess the safety and efficacy of oral administration of moxidectin in mice naturally infected with the fur mites Radfordia affinis. The natural infection was diagnosed in two colonies within a large academic institution by direct hair examination. Animals received moxidectin (1% Cydectin, FortDodge) at an oral dosage of approximately 2 mg/kg body weight by micropipette; administration was repeated after 15 days. Forty mice served as an untreated control group. Moxidectin treatment resulted in clinical improvement within a few days after initial treatment, and mites were eradicated from all infested animals at day 30. No side effects or signs of ill health were observed in any of the treated animals. To our knowledge, this is the first report of oral moxidectin for treatment of murine acariosis.
进行了一项田间试验，以评估口服莫昔克丁对自然感染兔痒螨的小鼠的安全性和有效性。通过直接毛发检查在一个大型学术机构的两个鼠群中诊断出自然感染。动物通过微量移液器以约2mg/kg体重的口服剂量接受莫昔克丁（1%的赛可新，法玛西亚动物保健公司）；15天后重复给药。40只小鼠作为未治疗的对照组。莫昔克丁治疗在初次治疗后的几天内使临床症状得到改善，并且在第30天时所有受感染动物身上的螨虫均被根除。在任何一只接受治疗的动物中均未观察到副作用或健康不良迹象。据我们所知，这是口服莫昔克丁治疗鼠螨病的首次报道。
