Mook Deborah M, Benjamin Kimberly A
Division of Animal Resources, Emory University , Atlanta, GA, USA.
J Am Assoc Lab Anim Sci. 2008 May;47(3):20-4.
A breeding colony consisting of 250 different strains of mice was treated with the topical acaricide selamectin for the mouse fur mite Myocoptes musculinus, with no apparent ill effect, suggesting that this drug is safe for use in mice. To further evaluate their efficacy in treating Myocoptes spp., we compared selamectin with another acaricide, moxidectin, in a controlled manner. Infested mice were treated with selamectin or moxidectin at the time of cage change, and a subset of mice was retreated 10 d later. Mice underwent routine cellophane tape examination of the pelage for 1 y. Although no adult mites were found in any group at 1 mo after treatment, egg casings were found in the selamectin treatment group as late as 6 mo after treatment, prompting concern about its effectiveness. Moxidectin used in combination with cage changing was effective in eradicating mites, with mice negative for traces of mites on cellophane tape examination of the pelage from months 2 through 12 after treatment.
一个由250种不同品系小鼠组成的繁殖群体，用外用杀螨剂塞拉菌素治疗小鼠皮螨肌螨，未出现明显不良影响，表明该药物对小鼠使用安全。为进一步评估其治疗肌螨属螨虫的效果，我们以对照方式将塞拉菌素与另一种杀螨剂莫昔克丁进行了比较。在更换笼子时，用塞拉菌素或莫昔克丁对受感染的小鼠进行治疗，一部分小鼠在10天后再次接受治疗。小鼠接受了为期1年的常规透明胶带检查以检测体表情况。尽管治疗后1个月时在任何组中均未发现成年螨虫，但在塞拉菌素治疗组中，直到治疗后6个月仍发现有卵壳，这引发了对其有效性的担忧。莫昔克丁与更换笼子相结合可有效根除螨虫，治疗后2至12个月，小鼠在体表透明胶带检查中未发现螨虫痕迹呈阴性。
