Guzzo L S, Saúde-Guimarães D A, Silva A C A, Lombardi J A, Guimarães H N, Grabe-Guimarães A
Laboratório de Farmacologia Experimental, Escola de Farmácia, Universidade Federal de Ouro Preto, Brazil.
J Ethnopharmacol. 2008 Feb 28;116(1):120-4. doi: 10.1016/j.jep.2007.11.006. Epub 2007 Nov 17.
Extracts from Lychnophora species are traditionally used in Brazil as anti-inflammatory, and to treat bruise, pain and rheumatism. The ethanolic extract of aerial parts of five species of Lychnophoras and one specie of Lychnophoriopsis were examined for the antinociceptive (hot-plate and writhing tests) and anti-inflammatory (carrageenan-induced paw oedema test) activity in mice, by oral and topical routes, respectively. In the hot-plate test, the Lychnophora pinaster (0.75 g/kg) and Lychnophora ericoides (1.50 g/kg) extracts significantly increased the time for licking of the paws. The species Lychnophora passerina, Lychnophoriopsis candelabrum and Lychnophora pinaster, using the dose of 0.75 g/kg, and Lychnophora ericoides and Lychnophora trichocarpha in both doses evaluated (0.75 and 1.50 g/kg) significantly reduced the number of writhes induced by acetic acid. The administration of Lychnophora pinaster and Lychnophora trichocarpha ointments, in both concentrations evaluated (5 and 10%, w/w), and Lychnophora passerina and Lychnophoriopsis candelabrum, in the concentration of 10%, significantly reduced the paw oedema measured 3 h after carrageenan administration, suggesting, for the first time, an anti-inflammatory activity upon topical administration of these species. The present work comparatively demonstrated the antinociceptive and anti-inflammatory activities of some Brazilian Lychnophoras.
在巴西，传统上使用灯笼草属植物提取物来消炎，并治疗瘀伤、疼痛和风湿病。分别通过口服和局部给药途径，对五种灯笼草属植物和一种拟灯笼草属植物地上部分的乙醇提取物在小鼠中的抗伤害感受（热板法和扭体试验）和抗炎（角叉菜胶诱导的爪肿胀试验）活性进行了检测。在热板试验中，松果灯笼草（0.75 g/kg）和埃里克灯笼草（1.50 g/kg）提取物显著延长了舔爪时间。使用0.75 g/kg剂量的过路灯笼草、烛台拟灯笼草和松果灯笼草，以及两种评估剂量（0.75和1.50 g/kg）的埃里克灯笼草和毛果灯笼草，均显著减少了乙酸诱导的扭体次数。在两种评估浓度（5%和10%，w/w）下，松果灯笼草和毛果灯笼草软膏，以及浓度为10%的过路灯笼草和烛台拟灯笼草软膏，在角叉菜胶给药3小时后显著减轻了爪肿胀，首次表明这些植物经局部给药具有抗炎活性。本研究比较证明了一些巴西灯笼草属植物的抗伤害感受和抗炎活性。
