Küpeli Esra, Kartal Murat, Aslan Sinem, Yesilada Erdem
Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler, Ankara, Turkey.
J Ethnopharmacol. 2006 Aug 11;107(1):32-7. doi: 10.1016/j.jep.2006.02.005. Epub 2006 Feb 28.
Extracts obtained from the root and aerial parts of various Eryngium (Apiaceae) species are used as folk remedy worldwide for the treatment of various inflammatory disorders. Ethanolic and aqueous extracts obtained from either aerial parts or roots of eight Eryngium species growing in Turkey, i.e., were evaluated for their in vivo anti-inflammatory and antinociceptive activities. Eryngium campestre, Eryngium creticum, Eryngium davisii, Eryngium falcatum, Eryngium isauricum, Eryngium kotschyi, Eryngium maritimum, and Eryngium trisectum. For the antinociceptive activity assessment p-benzoquinone-induced writhing test, and for anti-inflammatory activity carrageenan-induced hind paw oedema and TPA-induced ear oedema tests were employed in mice. According to the results of investigations, except Eryngium falcatum extracts, ethanol extracts either from the aerial parts or roots of Eryngium species showed apparent anti-inflammatory and antinociceptive activity. In spite of potent activity of the ethanol extract from Eryngium isauricum aerial parts was induced gastric damage. Aerial parts and roots of Eryngium maritimum and Eryngium kotschyi were found to possess most promising activities without including any apparent gastric damage.
从各种刺芹属（伞形科）植物的根和地上部分提取的提取物在世界各地被用作民间药物，用于治疗各种炎症性疾病。对生长在土耳其的8种刺芹属植物，即田野刺芹、克里特刺芹、戴维斯刺芹、镰叶刺芹、伊索里亚刺芹、科氏刺芹、海滨刺芹和三裂刺芹的地上部分或根的乙醇提取物和水提取物的体内抗炎和镇痛活性进行了评估。对于镇痛活性评估，采用对苯醌诱导的扭体试验；对于抗炎活性，采用角叉菜胶诱导的后爪水肿试验和佛波酯诱导的耳水肿试验对小鼠进行检测。根据研究结果，除镰叶刺芹提取物外，刺芹属植物地上部分或根的乙醇提取物均表现出明显的抗炎和镇痛活性。尽管伊索里亚刺芹地上部分的乙醇提取物具有较强的活性，但会引起胃损伤。发现海滨刺芹和科氏刺芹的地上部分和根具有最有前景的活性，且不包括任何明显的胃损伤。
