±-卡拉诺内酯A、±-心形内酯A及其11-去甲基类似物的化学拆分
Chemical resolution of +/- -calanolide A, +/- -cordatolide A and their 11-demethyl analogues.
作者信息
Ma Tao, Gao Qi, Chen Zhiwei, Wang Lin, Liu Gang
机构信息
Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2# Nan Wei Road, Beijing 100050, China.
出版信息
Bioorg Med Chem Lett. 2008 Feb 1;18(3):1079-83. doi: 10.1016/j.bmcl.2007.12.008. Epub 2007 Dec 10.
PMID:18155519
Abstract
The chemical resolution of (+/-)-calanolide A and (+/-)-cordatolide A into their corresponding optically active enantiomers is described. Their inhibitory activities against HIV-1 are tested in vitro.
摘要
描述了将（±）-卡拉诺内酯A和（±）-心叶内酯A化学拆分为其相应的旋光对映体的过程。并在体外测试了它们对HIV-1的抑制活性。
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