Cassien Mathieu, Mercier Anne, Thétiot-Laurent Sophie, Culcasi Marcel, Ricquebourg Emilie, Asteian Alice, Herbette Gaëtan, Bianchini Jean-Pierre, Raharivelomanana Phila, Pietri Sylvia
Aix Marseille Univ, CNRS, ICR , UMR 7273, SMBSO, 13397 Marseille , France.
Univ Polynésie Française, IFREMER, ILM, IRD, EIO UMR 241, 98702 Faa'a Tahiti, French Polynesia.
Antioxidants (Basel). 2021 Jan 30;10(2):199. doi: 10.3390/antiox10020199.
Tamanu oil from L. has long been used in traditional medicine. Ethanol extraction was found the best strategy for recovering bioactive compounds from the resin part of Tamanu oil, yielding two neutral and acidic resins fractions with high phenolics, flavonoids and pyranocoumarins concentrations. A further cascade of LPLC/HPLC separations of neutral and acidic resin fractions allowed identifying fifteen metabolites, and among them, calanolide D and 12-oxocalanolide A (both in neutral fraction) were first identified from a natural source. All these extracts, subfractions and isolated metabolites demonstrated increased free radical scavenging, antioxidant, anti-inflammatory, antimicrobial and antimycobacterial activity compared to Tamanu oil and its de-resinated lipid phase. Overall, these results could promote resinous ethanol-soluble Tamanu oil extracts as a useful multifaceted and renewable medicinal resource.
来自麻风树属的塔马努油长期以来一直用于传统医学。乙醇提取被发现是从塔马努油树脂部分回收生物活性化合物的最佳策略，可得到两种酚类、黄酮类和吡喃香豆素浓度高的中性和酸性树脂馏分。对中性和酸性树脂馏分进行进一步的低压液相色谱/高效液相色谱级联分离，可鉴定出15种代谢物，其中，卡拉诺内酯D和12-氧代卡拉诺内酯A（均在中性馏分中）首次从天然来源中鉴定出来。与塔马努油及其脱树脂脂质相相比，所有这些提取物、亚馏分和分离出的代谢物均表现出增强的自由基清除、抗氧化、抗炎、抗菌和抗分枝杆菌活性。总体而言，这些结果可促进树脂状乙醇可溶性塔马努油提取物成为一种有用的多方面可再生药用资源。
