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Research on heterocyclic compounds. XV. Substitution influence on the pharmacological activity in a series of imidazo[1,2-a]pyridines.

作者信息

Abignente E, Arena F, Avara P, Biniecka M, Luraschi E, Marmo E, Cazzola M, Filippelli W

出版信息

Farmaco Sci. 1983 Dec;38(12):911-28.

PMID:6607848
Abstract

We have taken into consideration a group of 28 imidazo [1,2-a]pyridine derivatives, some of which were already known, whereas the others have been synthesized and characterized to complete the series. Antiinflammatory, analgesic, antipyretic and ulcerogenic activities of such compounds were evaluated in comparison with indomethacin. The pharmacological data demonstrated the effects exerted on activity by the presence on the heterocyclic system of methyl substituents and/or an acidic moiety.

摘要

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