Abignente E, Arena F, Luraschi E, Saturnino C, Marmo E, Berrino L, Susanna V
Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università di Napoli, Italia.
Res Commun Chem Pathol Pharmacol. 1988 Aug;61(2):167-83.
A group of four acidic imidazo[1,2-c]pyrimidine derivatives were subjected to a series of tests in vivo in order to assess their pharmacological activity. Antiinflammatory activity was studied by means of the carrageenin-induced paw edema and pleurisy in rats. Hot plate test and writhing induced by acetic acid in mice were employed to evaluate analgesic activity, whereas the yeast-induced hyperthermia in rats was used to study antipyretic activity. The irritative and ulcerogenic action on the rat gastric mucosa was examined at higher doses. The inhibitory activity on the platelet malondialdehyde production was studied in order to obtain information about the mechanism of action of test compounds.
为评估其药理活性，对一组四种酸性咪唑并[1,2 - c]嘧啶衍生物进行了一系列体内试验。通过角叉菜胶诱导的大鼠爪肿胀和胸膜炎研究抗炎活性。采用热板试验和小鼠醋酸诱导扭体试验评估镇痛活性，而大鼠酵母诱导的体温过高用于研究解热活性。在较高剂量下检测对大鼠胃黏膜的刺激和致溃疡作用。研究对血小板丙二醛生成的抑制活性，以获取有关受试化合物作用机制的信息。
