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在应对铁缺乏时，AraC样转录调节因子DhbR是布鲁氏菌2308中2,3 - 二羟基苯甲酸生物合成基因最大程度表达所必需的。

The AraC-like transcriptional regulator DhbR is required for maximum expression of the 2,3-dihydroxybenzoic acid biosynthesis genes in Brucella abortus 2308 in response to iron deprivation.

作者信息

Anderson Eric S, Paulley James T, Roop R Martin

机构信息

Department of Microbiology and Immunology, East Carolina University School of Medicine, 600 Moye Boulevard, Greenville, NC 27834, USA.

出版信息

J Bacteriol. 2008 Mar;190(5):1838-42. doi: 10.1128/JB.01551-07. Epub 2007 Dec 21.

DOI:10.1128/JB.01551-07
PMID:18156262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2258684/
Abstract

Phenotypic evaluation of isogenic mutants derived from Brucella abortus 2308 indicates that the AlcR homolog DhbR (2,3-dihydroxybenzoic acid [2,3-DHBA] biosynthesis regulator) modulates the expression of the genes involved in 2,3-DHBA production, employing 2,3-DHBA or brucebactin as a coinducer.

摘要

源自流产布鲁氏菌2308的同基因突变体的表型评估表明，AlcR同源物DhbR（2,3-二羟基苯甲酸[2,3-DHBA]生物合成调节因子）利用2,3-DHBA或brucebactin作为共诱导剂来调节参与2,3-DHBA产生的基因的表达。

相似文献

1
The AraC-like transcriptional regulator DhbR is required for maximum expression of the 2,3-dihydroxybenzoic acid biosynthesis genes in Brucella abortus 2308 in response to iron deprivation.在应对铁缺乏时，AraC样转录调节因子DhbR是布鲁氏菌2308中2,3 - 二羟基苯甲酸生物合成基因最大程度表达所必需的。
J Bacteriol. 2008 Mar;190(5):1838-42. doi: 10.1128/JB.01551-07. Epub 2007 Dec 21.
2
Genetic organization and iron-responsive regulation of the Brucella abortus 2,3-dihydroxybenzoic acid biosynthesis operon, a cluster of genes required for wild-type virulence in pregnant cattle.流产布鲁氏菌2,3-二羟基苯甲酸生物合成操纵子的遗传组织与铁响应调控，该操纵子是孕牛野生型毒力所需的一组基因。
Infect Immun. 2003 Apr;71(4):1794-803. doi: 10.1128/IAI.71.4.1794-1803.2003.
3
Irr regulates brucebactin and 2,3-dihydroxybenzoic acid biosynthesis, and is implicated in the oxidative stress resistance and intracellular survival of Brucella abortus.Irr调节brucebactin和2,3-二羟基苯甲酸的生物合成，并与牛布鲁氏菌的氧化应激抗性和细胞内存活有关。
Microbiology (Reading). 2006 Sep;152(Pt 9):2591-2598. doi: 10.1099/mic.0.28782-0.
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The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice.2,3-二羟基苯甲酸这种铁载体对于布鲁氏菌在BALB/c小鼠中的致病性并非必需。
Infect Immun. 1999 May;67(5):2615-8. doi: 10.1128/IAI.67.5.2615-2618.1999.
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Production of the siderophore 2,3-dihydroxybenzoic acid is required for wild-type growth of Brucella abortus in the presence of erythritol under low-iron conditions in vitro.在体外低铁条件下，布鲁氏菌在赤藓糖醇存在时野生型生长需要产生铁载体2,3 - 二羟基苯甲酸。
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Brucella abortus strain 2308 produces brucebactin, a highly efficient catecholic siderophore.流产布鲁氏菌2308菌株产生brucebactin，一种高效的儿茶酚型铁载体。
Microbiology (Reading). 2002 Feb;148(Pt 2):353-360. doi: 10.1099/00221287-148-2-353.
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Identification of 2,3-dihydroxybenzoic acid as a Brucella abortus siderophore.鉴定2,3 - 二羟基苯甲酸为流产布鲁氏菌的铁载体。
Infect Immun. 1992 Nov;60(11):4496-503. doi: 10.1128/iai.60.11.4496-4503.1992.
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Effect of entF deletion on iron acquisition and erythritol metabolism by Brucella abortus 2308.entF 缺失对布鲁氏菌 2308 铁摄取和赤藓糖醇代谢的影响。
FEMS Microbiol Lett. 2011 Mar;316(1):1-6. doi: 10.1111/j.1574-6968.2010.02186.x. Epub 2011 Jan 10.
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Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria.流产布鲁氏菌铁载体2,3-二羟基苯甲酸（DHBA）有助于该细菌在细胞内存活。
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The bhuQ gene encodes a heme oxygenase that contributes to the ability of Brucella abortus 2308 to use heme as an iron source and is regulated by Irr.bhuQ基因编码一种血红素加氧酶，该酶有助于布鲁氏菌2308利用血红素作为铁源，并受Irr调控。
J Bacteriol. 2012 Aug;194(15):4052-8. doi: 10.1128/JB.00367-12. Epub 2012 May 25.

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本文引用的文献

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Brucella abortus requires the heme transporter BhuA for maintenance of chronic infection in BALB/c mice.布鲁氏菌流产亚种在BALB/c小鼠中维持慢性感染需要血红素转运蛋白BhuA。
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Computational reconstruction of iron- and manganese-responsive transcriptional networks in alpha-proteobacteria.α-变形菌中铁和锰响应转录网络的计算重建
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PchR-box recognition by the AraC-type regulator PchR of Pseudomonas aeruginosa requires the siderophore pyochelin as an effector.铜绿假单胞菌的AraC型调节因子PchR对PchR-box的识别需要铁载体绿脓菌素作为效应物。
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The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice.流产布鲁氏菌的铜锌超氧化物歧化酶对于在实验感染小鼠中抵抗鼠巨噬细胞的氧化杀伤以及野生型毒力至关重要。
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Genetic organization and iron-responsive regulation of the Brucella abortus 2,3-dihydroxybenzoic acid biosynthesis operon, a cluster of genes required for wild-type virulence in pregnant cattle.流产布鲁氏菌2,3-二羟基苯甲酸生物合成操纵子的遗传组织与铁响应调控，该操纵子是孕牛野生型毒力所需的一组基因。
Infect Immun. 2003 Apr;71(4):1794-803. doi: 10.1128/IAI.71.4.1794-1803.2003.
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RirA, an iron-responsive regulator in the symbiotic bacterium Rhizobium leguminosarum.RirA，一种豆科根瘤菌共生细菌中的铁响应调节因子。
Microbiology (Reading). 2002 Dec;148(Pt 12):4059-4071. doi: 10.1099/00221287-148-12-4059.
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Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria.流产布鲁氏菌铁载体2,3-二羟基苯甲酸（DHBA）有助于该细菌在细胞内存活。
Microb Pathog. 2002 May;32(5):239-48. doi: 10.1006/mpat.2002.0500.