布鲁氏菌的金属获取和毒力。
Metal acquisition and virulence in Brucella.
机构信息
Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA.
出版信息
Anim Health Res Rev. 2012 Jun;13(1):10-20. doi: 10.1017/S1466252312000047. Epub 2012 May 25.
Abstract
Similar to other bacteria, Brucella strains require several biologically essential metals for their survival in vitro and in vivo. Acquiring sufficient levels of some of these metals, particularly iron, manganese and zinc, is especially challenging in the mammalian host, where sequestration of these micronutrients is a well-documented component of both the innate and acquired immune responses. This review describes the Brucella metal transporters that have been shown to play critical roles in the virulence of these bacteria in experimental and natural hosts.
摘要
类似于其他细菌，布鲁氏菌菌株在体外和体内生存需要几种生物必需的金属。在哺乳动物宿主中，获得这些金属（特别是铁、锰和锌）的足够水平特别具有挑战性，因为这些微量元素的隔离是先天和获得性免疫反应的一个很好的记录部分。本综述描述了已被证明在实验和自然宿主中对这些细菌的毒力起着关键作用的布鲁氏菌金属转运体。
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本文引用的文献
1
SodA is a major metabolic antioxidant in Brucella abortus 2308 that plays a significant, but limited, role in the virulence of this strain in the mouse model.
Microbiology (Reading). 2012 Jul;158(Pt 7):1767-1774. doi: 10.1099/mic.0.059584-0. Epub 2012 May 3.
2
Zinc metalloenzymes as new targets against the bacterial pathogen Brucella.
J Inorg Biochem. 2012 Jun;111:138-45. doi: 10.1016/j.jinorgbio.2011.10.019. Epub 2011 Dec 1.
3
Mur regulates the gene encoding the manganese transporter MntH in Brucella abortus 2308.
J Bacteriol. 2012 Feb;194(3):561-6. doi: 10.1128/JB.05296-11. Epub 2011 Nov 18.
4
Brucella genomics as we enter the multi-genome era.
Brief Funct Genomics. 2011 Nov;10(6):334-41. doi: 10.1093/bfgp/elr026. Epub 2011 Sep 19.
5
A review of Brucella infection in marine mammals, with special emphasis on Brucella pinnipedialis in the hooded seal (Cystophora cristata).
Vet Res. 2011 Aug 5;42(1):93. doi: 10.1186/1297-9716-42-93.
6
The iron-responsive regulator irr is required for wild-type expression of the gene encoding the heme transporter BhuA in Brucella abortus 2308.
J Bacteriol. 2011 Oct;193(19):5359-64. doi: 10.1128/JB.00372-11. Epub 2011 Jul 29.
7
Protective live oral brucellosis vaccines stimulate Th1 and th17 cell responses.
Infect Immun. 2011 Oct;79(10):4165-74. doi: 10.1128/IAI.05080-11. Epub 2011 Jul 18.
8
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9
Effect of entF deletion on iron acquisition and erythritol metabolism by Brucella abortus 2308.
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10
Iron homeostasis in Brucella abortus: the role of bacterioferritin.
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