2,3-二羟基苯甲酸这种铁载体对于布鲁氏菌在BALB/c小鼠中的致病性并非必需。
The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice.
作者信息
Bellaire B H, Elzer P H, Baldwin C L, Roop R M
机构信息
Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport, Louisiana 71130-3932, USA.
出版信息
Infect Immun. 1999 May;67(5):2615-8. doi: 10.1128/IAI.67.5.2615-2618.1999.
Abstract
2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella, and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant (DeltaentC) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.
摘要
2,3 - 二羟基苯甲酸（DHBA）是已报道的布鲁氏菌属唯一的铁载体，先前的研究表明，DHBA可能有助于这些微生物在宿主巨噬细胞中持续存在的能力。然而，利用从强毒流产布鲁氏菌2308构建的同基因铁载体突变体（DeltaentC），我们发现，在培养的小鼠巨噬细胞中复制或在BALB/c小鼠模型中建立和维持慢性感染并不需要DHBA的产生。
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