Gas6通过增强内皮细胞、血小板和白细胞之间的相互作用来促进炎症反应。
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
作者信息
Tjwa Marc, Bellido-Martin Lola, Lin Yuan, Lutgens Esther, Plaisance Stéphane, Bono Françoise, Delesque-Touchard Nathalie, Hervé Caroline, Moura Rute, Billiau An D, Aparicio Cristina, Levi Marcel, Daemen Mat, Dewerchin Mieke, Lupu Florea, Arnout Jef, Herbert Jean-Marc, Waer Mark, García de Frutos Pablo, Dahlbäck Björn, Carmeliet Peter, Hoylaerts Marc F, Moons Lieve
机构信息
Department of Transgene Technology and Gene Therapy, Flanders Institute of Biotechnology (VIB), Leuven, Belgium.
出版信息
Blood. 2008 Apr 15;111(8):4096-105. doi: 10.1182/blood-2007-05-089565. Epub 2007 Dec 21.
The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.
Gas6在内皮细胞（EC）功能中的作用尚未完全明确。在此我们报告，Gas6在体外可放大内皮细胞对炎症刺激的激活反应。在体内，Gas6促进并加速循环血小板和白细胞在活化内皮上的滞留，以及循环中血小板 - 白细胞结合物的形成和在内皮上的滞留。此外，在炎症小鼠模型（内毒素血症、血管炎、心脏移植）中，Gas6促进白细胞渗出、炎症和血栓形成。因此，Gas6放大内皮细胞激活，从而在炎症期间增强内皮细胞、血小板和白细胞之间的相互作用中发挥关键作用。
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