Kim Sunhee, Krynyckyi Borys R, Machac Josef, Kim Chun K
Division of Nuclear Medicine, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA.
Eur J Nucl Med Mol Imaging. 2008 May;35(5):984-9. doi: 10.1007/s00259-007-0670-4. Epub 2007 Dec 22.
It has been reported that the prevalence of (18)F fluorodeoxyglucose (FDG) uptake in brown adipose tissue (BAT) is related to outdoor temperature, i.e., more frequent during the colder periods of the year. The purpose of this study was to assess the temporal relationship between BAT FDG uptake and temperature. We correlated the prevalence of BAT with average temperatures (divided into five temperature ranges) of seven different durations.
One thousand four hundred ninety-five consecutive FDG Positron emission tomography (PET) studies in 1,159 patients (566 male and 593 female, mean age = 60.4 years) were retrospectively reviewed. FDG uptake with distinct patterns compatible with BAT was identified by a consensus of two readers. The local daily average temperature from January 2000 to November 2003 (beginning 60 days before the date of first PET scan) were obtained, and 2-, 3-, 7-, 14-, 30-, and 60-day average temperatures before the date of a PET study were calculated. The prevalence of BAT FDG uptake was correlated with these various average temperatures.
The daily, 2-day, 3-day, and 7-day average temperature had an inverse relation with the prevalence of BAT, i.e., the lower the temperature, the higher prevalence of BAT. When the temperature was averaged over 14 days or longer, this inverse relationship between the temperature and the prevalence of BAT was no longer preserved.
Our data suggest that increased FDG uptake in BAT occurs more often as an acute response to cold weather (1-7 days) rather than to prolonged periods of average cold weather.
据报道，棕色脂肪组织（BAT）中（18）F氟脱氧葡萄糖（FDG）摄取的患病率与室外温度有关，即在一年中较冷的时期更为频繁。本研究的目的是评估BAT FDG摄取与温度之间的时间关系。我们将BAT的患病率与七个不同时间段的平均温度（分为五个温度范围）进行了关联。
回顾性分析了1159例患者（566例男性和593例女性，平均年龄=60.4岁）的1495例连续FDG正电子发射断层扫描（PET）研究。由两位阅片者达成共识，确定与BAT相符的具有明显模式的FDG摄取。获取了2000年1月至2003年11月（首次PET扫描日期前60天开始）的当地每日平均温度，并计算了PET研究日期前2天、3天、7天、14天、30天和60天的平均温度。将BAT FDG摄取的患病率与这些不同的平均温度进行关联。
每日、2天、3天和7天的平均温度与BAT的患病率呈负相关，即温度越低，BAT的患病率越高。当温度平均超过14天或更长时间时，温度与BAT患病率之间的这种负相关关系不再存在。
我们的数据表明，BAT中FDG摄取增加更常是对寒冷天气（1 - 7天）的急性反应，而不是对长期平均寒冷天气的反应。
