Adegnika Ayola A, Agnandji Selidji T, Chai Sanders K, Ramharter Michael, Breitling Lutz, Kendjo Eric, Issifou Saadou, Yazdanbakhsh Maria, Kombila Maryvonne, Kremsner Peter G
Albert Schweitzer Hospital Medical Research Unit, Lambaréné, Gabon.
Wien Klin Wochenschr. 2007;119(23-24):712-6. doi: 10.1007/s00508-007-0907-z.
Gestation is a unique physiologic state that carries with it several immunologic consequences and results in changing susceptibility to various diseases. In contrast to the well recognized excess vulnerability of primiparous women to Plasmodium falciparum infection in areas of high malaria transmission, it is not known whether pregnancy is associated with a higher prevalence of helminth infection. In Lambaréné, Gabon, 105 pregnant women were recruited and matched with non-gravid female controls. The prevalence of intestinal helminths was 66% (n=58) in the pregnant participants and 36% (n=32) in the non-pregnant controls (P<0.001). In multivariate analysis the pregnancy status was an independent risk factor for being infected with intestinal helminths (AOR and 95% CI: 3.0 [1.4-5.9]). These data show a previously undescribed susceptibility pattern of pregnant women to intestinal helminth infection in a sub-Saharan African community.
妊娠是一种独特的生理状态，会带来多种免疫方面的影响，并导致对各种疾病的易感性发生变化。与在疟疾高传播地区初产妇对恶性疟原虫感染的高度易感性已得到充分认识相反，目前尚不清楚妊娠是否与蠕虫感染的较高患病率相关。在加蓬的兰巴雷内，招募了105名孕妇，并与非妊娠女性对照进行匹配。妊娠参与者中肠道蠕虫的患病率为66%（n = 58），非妊娠对照中为36%（n = 32）（P<0.001）。在多变量分析中，妊娠状态是感染肠道蠕虫的独立危险因素（比值比和95%置信区间：3.0 [1.4 - 5.9]）。这些数据显示了撒哈拉以南非洲社区孕妇对肠道蠕虫感染的一种此前未被描述的易感性模式。
