简短报告：在不使用镇静剂的情况下为患有自闭症的幼儿获取结构磁共振成像（MRI）数据的方法。
Brief report: methods for acquiring structural MRI data in very young children with autism without the use of sedation.
作者信息
Nordahl Christine Wu, Simon Tony J, Zierhut Cynthia, Solomon Marjorie, Rogers Sally J, Amaral David G
机构信息
M.I.N.D. Institute and Department of Psychiatry and Behavioral Sciences, University of California at Davis, 2805 50th Street, Sacramento, CA, 95817, USA.
出版信息
J Autism Dev Disord. 2008 Sep;38(8):1581-90. doi: 10.1007/s10803-007-0514-x. Epub 2007 Dec 22.
Abstract
We describe a protocol with which we achieved a 93% success rate in acquiring high quality MRI scans without the use of sedation in 2.5-4.5 year old children with autism, developmental delays, and typical development. Our main strategy was to conduct MRIs during natural nocturnal sleep in the evenings after the child's normal bedtime. Alternatively, with some older and higher functioning children, the MRI was conducted while the child was awake and watching a video. Both strategies relied heavily on the creation of a child and family friendly MRI environment and the involvement of parents as collaborators in the project. Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases.
摘要
我们描述了一种方案，通过该方案，我们在未使用镇静剂的情况下，成功为患有自闭症、发育迟缓以及发育正常的2.5至4.5岁儿童获取高质量MRI扫描，成功率达93%。我们的主要策略是在孩子正常就寝时间后的夜间自然睡眠期间进行MRI检查。另外，对于一些年龄较大、功能较高的儿童，在其清醒并观看视频时进行MRI检查。这两种策略都严重依赖于营造一个对儿童和家庭友好的MRI环境，以及让父母作为项目合作者参与其中。在大多数情况下，不使用镇静剂或麻醉剂为非常年幼的自闭症、发育正常及发育迟缓儿童进行扫描是可行的。
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