The Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and the Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
Adv Neurobiol. 2024;40:491-509. doi: 10.1007/978-3-031-69491-2_17.
Since the early 1990s, there have literally been thousands of reports related to magnetic resonance imaging of the autistic brain. The goals of these studies have ranged from identifying the earliest biological predictors of an autistic diagnosis to determining brain systems most altered in autistic individuals. Some of the later works attempt to use distinct patterns of brain alterations to help define more homogenous subtypes of autism. Far less work has been done to identify brain changes that are associated with therapeutic interventions. In this chapter, we will touch on all of these efforts as they relate to the general topic of the usefulness of brain imaging as a biomarker of autism.
自 20 世纪 90 年代初以来，已经有数千篇与自闭症患者大脑的磁共振成像相关的报告。这些研究的目的从确定自闭症诊断的最早生物学预测因子到确定自闭症个体大脑系统中最受影响的系统都有涉及。其中一些较晚的研究工作试图使用大脑改变的不同模式来帮助定义自闭症更同质的亚型。但很少有研究致力于确定与治疗干预相关的大脑变化。在本章中，我们将涉及所有这些努力，因为它们与大脑成像作为自闭症生物标志物的有用性这一主题有关。
