Ahishali Emel, Boztas Gungor, Akyuz Filiz, Ibrisim Duygu, Poturoglu Sule, Pinarbasi Binnur, Ozdil Sadakat, Mungan Zeynel
Department of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey.
Dig Dis Sci. 2008 Aug;53(8):2156-9. doi: 10.1007/s10620-007-0128-3. Epub 2007 Dec 20.
Abnormal immune response to gliadin, genetic, and environmental factors play a role in the pathogenesis of celiac disease (CD). Non-responsiveness to hepatitis B virus (HBV) vaccination is related to genetic features. Certain human leukocyte antigen (HLA) genotypes are more prevalent among non-responders to HBV vaccination. There is also a strong relationship between CD and these HLA genotypes. This study investigates the relationship between CD and non-responsiveness to HBV vaccination, with an emphasis on genotypic co-incidence. No statistically significant difference was noted between the ages and gender of CD patients and control subjects. Baseline serum IgA, IgM, and IgG levels of all CD patients were normal. Responsiveness to HBV vaccination was observed in 17 (68%) CD patients and all (100%) control subjects (P = 0.006). In conclusion, CD should also be sought in unresponders to HBV vaccine who are not immunosuppressed.
对麦醇溶蛋白的异常免疫反应、遗传因素和环境因素在乳糜泻（CD）的发病机制中起作用。对乙型肝炎病毒（HBV）疫苗接种无反应与遗传特征有关。某些人类白细胞抗原（HLA）基因型在对HBV疫苗接种无反应者中更为普遍。CD与这些HLA基因型之间也存在密切关系。本研究调查了CD与对HBV疫苗接种无反应之间的关系，重点是基因型巧合。CD患者与对照受试者的年龄和性别之间未观察到统计学上的显著差异。所有CD患者的基线血清IgA、IgM和IgG水平均正常。17例（68%）CD患者和所有（100%）对照受试者观察到对HBV疫苗接种有反应（P = 0.006）。总之，在未免疫抑制的HBV疫苗无反应者中也应筛查CD。
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