Zhang Guifang, David Anand, Wiedmann Timothy Scott
University of Minnesota, Department of Pharmaceutics, Minneapolis, Minnesota 55455, USA.
J Aerosol Med. 2007 Winter;20(4):408-16. doi: 10.1089/jam.2007.0622.
The output and particle size distribution of several series of aqueous solutions were measured to define quantitatively the practical limits of the solution properties acceptable for aerosol production by the aeroneb micropump nebulizer. Aerosol output measurements were made gravimetrically and the particle size distributions were obtained by laser diffractometry. Solution properties were obtained from the literature by interpolation of the best-fit curve of the property plotted as a function of composition. For nonionic solutes, addition of sodium chloride dramatically increased the output rate and also decreased the droplet size at low solute concentrations. Increasing viscosity also caused a significant decrease in output. Cesium chloride displayed increased output rate with concentration due to the rising density. Based on calculations with the number of apertures and oscillatory frequency, low output rates appeared to be a consequence of apertures failing to produce a droplet with each oscillation. Overall, ionic strength, density, surface tension, and viscosity affected the output rate in a manner that can be now empirically predicted.
测量了几个系列水溶液的输出量和粒径分布，以定量确定通过Aeroneb微泵雾化器产生气溶胶可接受的溶液性质的实际限度。通过重量法进行气溶胶输出量测量，并通过激光衍射法获得粒径分布。溶液性质是通过对文献中作为组成函数绘制的性质的最佳拟合曲线进行插值得到的。对于非离子溶质，在低溶质浓度下添加氯化钠会显著提高输出速率，并减小液滴尺寸。粘度增加也会导致输出量显著下降。由于密度增加，氯化铯的输出速率随浓度增加。根据孔径数量和振荡频率的计算，低输出速率似乎是由于孔径在每次振荡时未能产生液滴所致。总体而言，离子强度、密度、表面张力和粘度对输出速率的影响方式现在可以凭经验预测。
