Cai B L, Gong L S, Ye J P
Department of Medicine, Ruijin Hospital of Shanghai Second Medical University.
Zhonghua Nei Ke Za Zhi. 1991 Nov;30(11):688-91, 730.
Left ventricular (LV) diastolic filling was examined by Doppler echocardiography in 239 patients with essential hypertension and 100 normal subjects. The Doppler study showed an inverse correlation between age and early diastolic peak velocity (PVE, r-0.201, P less than 0.05) [and a positive correlation between age and late diastolic peak velocity (PVA, r = 0.202, P less than 0.05) in normal subjects. Isovolumic relaxation time and late diastolic filling time were prolonged, PVA, A/E and Ai elevated, PVE, E/A and Ei/Ai as well as total filling time decreased in patients with hypertension as compared with the values found in the normal subjects (P less than 0.05 to 0.01). The results showed definite impairement of LV diastolic function in hypertensive patients. PVA correlated positively with systolic blood pressure (r = 0.68, P less than 0.01) and modestly with left atrial dimension in the hypertensives. No significant differences were found in FS and EF between the two study populations, indicating that LV filling abnormalities may occur early in patients with hypertension, even at a time when systolic performance has not yet been affected.
采用多普勒超声心动图对239例原发性高血压患者和100例正常受试者的左心室舒张期充盈情况进行了检查。多普勒研究显示，正常受试者中，年龄与舒张早期峰值速度（PVE，r=-0.201，P<0.05）呈负相关，年龄与舒张晚期峰值速度（PVA，r=0.202，P<0.05）呈正相关。与正常受试者相比，高血压患者的等容舒张时间和舒张晚期充盈时间延长，PVA、A/E和Ai升高，PVE、E/A和Ei/Ai以及总充盈时间降低（P<0.05至0.01）。结果显示高血压患者左心室舒张功能存在明显损害。在高血压患者中，PVA与收缩压呈正相关（r=0.68，P<0.01），与左心房内径呈中度相关。两个研究人群的FS和EF无显著差异，表明高血压患者左心室充盈异常可能在早期出现，甚至在收缩功能尚未受影响时就已发生。
