核酶催化再探讨：水是否参与其中？
Ribozyme catalysis revisited: is water involved?
作者信息
Walter Nils G
机构信息
Department of Chemistry, Single Molecule Analysis Group, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48019-1055, USA.
出版信息
Mol Cell. 2007 Dec 28;28(6):923-9. doi: 10.1016/j.molcel.2007.12.001.
Abstract
Enzymatic catalysis by RNA was discovered 25 years ago, yet mechanistic insights are emerging only slowly. Thought to be metalloenzymes at first, some ribozymes proved more versatile than anticipated when shown to utilize their own functional groups for catalysis. Recent evidence suggests that some may also judiciously place structural water molecules to shuttle protons in acid-base catalyzed reactions.
摘要
RNA的酶促催化作用是25年前发现的，但对其作用机制的深入了解仍进展缓慢。一些核酶最初被认为是金属酶，但后来发现它们利用自身官能团进行催化，比预期的更为多样。最近的证据表明，有些核酶还可能巧妙地利用结构水分子在酸碱催化反应中传递质子。
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