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舒林酸可预防大鼠胃十二指肠反流诱导的食管腺癌。

Sulindac prevents esophageal adenocarcinomas induced by gastroduodenal reflux in rats.

作者信息

Kim Sung Wook, Jang Tae Jung, Jung Ki Hoon, Suh Jung Il

机构信息

Departments of Gastroenterology, Dongguk University College of Medicine, Kyongju, Korea.

出版信息

Yonsei Med J. 2007 Dec 31;48(6):1020-7. doi: 10.3349/ymj.2007.48.6.1020.

DOI:10.3349/ymj.2007.48.6.1020
PMID:18159596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2628171/
Abstract

PURPOSE

It is known that cyclooxygenase (COX)-2 expression is increased in Barrett's esophagus and esophageal adenocarcinomas. We studied COX-2 expression and the effect sulindac has on the genesis of Barrett's esophagus and adenocarcinoma in rats undergoing esophagogastroduodenal anastomosis (EGDA).

MATERIALS AND METHODS

Fifty-one rats were divided into a control group (n=27), a 500 ppm sulindac-treated group (n=15) and 1000 ppm sulindac-treated group (n=9). Randomly selected rats were killed by diethyl ether inhalation at 20 and 40 weeks after surgery.

RESULTS

At 40 weeks, rats treated with 1000 ppm sulindac showed narrower esophageal diameter and milder inflammation than the control rats. At 40 weeks, the incidence of Barrett's esophagus was similar between control and sulindac-treated groups, but the incidence of adenocarcinoma was significantly lower in the 1000 ppm sulindac-treated group than either the control or 500 ppm sulindac-treated groups. COX-2 was significantly increased in the lower esophagus of control rats killed at 40 weeks. Cyclin D1 expression was negligible in the sulindac- treated group compared with the control group.

CONCLUSION

We suggest that the chemopreventive effect of sulindac is related to decreased COX-2 and cyclin D1 expression, which may be influenced by reduced inflammation.

摘要

目的

已知环氧化酶（COX）-2在巴雷特食管和食管腺癌中表达增加。我们研究了COX-2的表达以及舒林酸对接受食管胃十二指肠吻合术（EGDA）的大鼠巴雷特食管和腺癌发生的影响。

材料与方法

51只大鼠分为对照组（n = 27）、500 ppm舒林酸治疗组（n = 15）和1000 ppm舒林酸治疗组（n = 9）。在术后20周和40周，通过吸入乙醚随机处死所选大鼠。

结果

在40周时，接受1000 ppm舒林酸治疗的大鼠食管直径比对照大鼠窄，炎症也较轻。在40周时，对照组和舒林酸治疗组之间巴雷特食管的发生率相似，但1000 ppm舒林酸治疗组腺癌的发生率明显低于对照组或500 ppm舒林酸治疗组。在40周处死的对照大鼠的食管下段，COX-2显著增加。与对照组相比，舒林酸治疗组细胞周期蛋白D1的表达可忽略不计。

结论

我们认为舒林酸的化学预防作用与COX-2和细胞周期蛋白D1表达降低有关，这可能受炎症减轻的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/a0fdacfa99af/ymj-48-1020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/51e9db20714f/ymj-48-1020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/1c014e4eb246/ymj-48-1020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/accc87179b2e/ymj-48-1020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/df78df6648d2/ymj-48-1020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/652bf62aa8b2/ymj-48-1020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/a0fdacfa99af/ymj-48-1020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/51e9db20714f/ymj-48-1020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/1c014e4eb246/ymj-48-1020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/accc87179b2e/ymj-48-1020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/df78df6648d2/ymj-48-1020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/652bf62aa8b2/ymj-48-1020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5a/2628171/a0fdacfa99af/ymj-48-1020-g006.jpg

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本文引用的文献

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2
The molecular biology of esophageal adenocarcinoma.食管腺癌的分子生物学
J Surg Oncol. 2005 Dec 1;92(3):169-90. doi: 10.1002/jso.20359.
3
Cyclooxygenase-2 expression and cell proliferation are increased in MUC2-positive area of columnar-lined esophagus.在柱状上皮化生食管的MUC2阳性区域，环氧化酶-2表达和细胞增殖增加。
巴雷特食管：我们目前的状况如何？
Saudi J Gastroenterol. 2009 Jan;15(1):2-10. doi: 10.4103/1319-3767.45046.
Pathol Int. 2005 Sep;55(9):546-9. doi: 10.1111/j.1440-1827.2005.01867.x.
4
The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15.传统的非甾体抗炎药舒林酸硫化物通过NAG-1/MIC-1/GDF-15的表达来抑制卵巢癌细胞的生长。
Mol Cancer Ther. 2005 Mar;4(3):487-93. doi: 10.1158/1535-7163.MCT-04-0201.
5
Nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.非甾体抗炎药与食管癌和胃癌风险
Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):444-50. doi: 10.1158/1055-9965.EPI-04-0467.
6
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