[听觉脑干反应及畸变产物耳声发射在糖尿病患者听力损失临床检测中的应用]

[Application of auditory brainstem response and distortion product otoacoustic emission in the clinical detection of hearing loss in patients with diabetes mellitus].

作者信息

Li Juan, Zhang Tianyu, Shen Jianzhong, Gong Jingrong, Zhu Jingyan, Wang Hongli, Zhou Yang

机构信息

Department of Otolaryngology, the Fifth Hospital, Fudan University, Shanghai, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Oct;21(19):875-9.

PMID:18159767

Abstract

OBJECTIVE

To study the characteristic of hearing loss and the changes of the auditory brainstem response and distortion product otoacoustic emission in diabetics.

METHOD

General information of 136 diabetics were investigated whether had the complication of capillary vessel and hearing loss with self-made questionnaire at random. 136 cases (272 ears) were tested with ABR and DPOAE. They were divided into A, B, C, D four groups according to the age of per ten years (30-70 years). Other 120 (240 ears) matched healthy adult were enrolled in the control group. The pure tone threshold (PTT), acoustic impedance, ABR and DPOAE results were compared between the four groups and the control group, and then made statistical analysis.

RESULT

When comparing to the control group, the interpeak latency I-V and ABR response were no significant difference between patients at the stage of 30 years. Not only the threshold of wave V was elevated with aging in patients over 40 years, but the amplitude of the peak latencies of waves III and V were lessening, and the interpeak latency III-V and I-V were prolonged between patients at the stage of 60 years, which had significant difference compared with age-matched patients (P < 0.05). The inducing rate of DPOAE were 100% in the test and control group, but the amplitude of DPOAE declined ranged from 1 to 8 kHz in patients with early diabetes mellitus and were significantly reduced at 4 kHz, which had significant difference compared with age-matched patients (P < 0.05).

CONCLUSION

The majority of patients with diabetes mellitus had slight and moderate hearing loss gradually. The ABR and the threshold of ABR response were varied with the age and sex of patients, and whether had the complication of capillary vessel, but were not related to its type and disease course. The DPOAE can comprehend the cochlear disorder in patients with early diabetes mellitus.

摘要

目的

研究糖尿病患者听力损失特点及听性脑干反应和畸变产物耳声发射的变化。

方法

采用自制问卷对136例糖尿病患者的一般资料进行调查，随机了解其是否有微血管并发症及听力损失情况。对136例患者（272耳）进行听性脑干反应（ABR）和畸变产物耳声发射（DPOAE）测试。按每十岁年龄段（30 - 70岁）分为A、B、C、D四组。另选取120例（240耳）匹配的健康成年人作为对照组。比较四组与对照组的纯音听阈（PTT）、声阻抗、ABR及DPOAE结果，并进行统计学分析。

结果

与对照组相比，30岁阶段患者的ABR波峰间期I - V及ABR反应差异无统计学意义。40岁以上患者不仅V波阈值随年龄升高，而且60岁阶段患者的III波和V波峰潜伏期幅值减小，III - V及I - V波峰间期延长，与同年龄段患者相比差异有统计学意义（P < 0.05）。试验组和对照组的DPOAE引出率均为100%，但早期糖尿病患者1 - 8 kHz的DPOAE幅值下降，4 kHz时显著降低，与同年龄段患者相比差异有统计学意义（P < 0.05）。