诱导猿猴病毒40转化的仓鼠细胞后，从宿主细胞DNA中切除病毒DNA。
Excision of viral DNA from host cell DNA after induction of simian virus 40-transformed hamster cells.
作者信息
Rakusanova T, Kaplan J C, Smales W P, Black P H
出版信息
J Virol. 1976 Jul;19(1):279-85. doi: 10.1128/JVI.19.1.279-285.1976.
Abstract
Simian virus 40-transformed hamster cells were induced to produce infectious virus by treatment with mitomycin C or gamma-irradiation. A portion of the simian virus-40 DNA, which is integrated into the host cell genome in uninduced cells, was recovered in a pool of relatively low-molecular-weight DNA early after induction treatment in the absence of DNA replication. The data indicte that excision of the viral genome occurs subsequent to the induction stimulus.
摘要
用丝裂霉素C或γ射线照射处理猿猴病毒40转化的仓鼠细胞，可诱导其产生感染性病毒。在未诱导的细胞中整合到宿主细胞基因组中的一部分猿猴病毒40 DNA，在诱导处理后早期、DNA复制不存在的情况下，在一组相对低分子量的DNA中被回收。数据表明病毒基因组的切除发生在诱导刺激之后。
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