Rabczyński Maciej, Jakobsche Urszula, Adamiec Rajmund
Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii Akademii Medyczne, Wrocław.
Przegl Lek. 2007;64(6):416-8.
Involvement of infection agents in pathogenesis of atherosclerosis was described in several studies, particularly in patients with acute coronary syndrome or ischemic stroke. However, in very few studies an association of serological markers of chronic infection with peripheral occlusive artery disease was analysed. The prevalence and concentration of immunoglobulin G and A to Chlamydia pneumoniae and immunoglobulin G to CMV were measured in sera of 31 participants suffering from peripheral occlusive artery disease. Significant difference in the prevalance of immunoglobulin G to C. pneumoniae and CMV between study and control groups was documented. There was no such association in reference to immunoglobulin A to C. pneumoniae index. Serum concentration of all measured antibodies were significantly higher in the study group than in control.
多项研究描述了感染因子在动脉粥样硬化发病机制中的作用，特别是在急性冠状动脉综合征或缺血性中风患者中。然而，很少有研究分析慢性感染的血清学标志物与外周动脉闭塞性疾病之间的关联。测量了31名外周动脉闭塞性疾病患者血清中针对肺炎衣原体的免疫球蛋白G和A以及针对巨细胞病毒的免疫球蛋白G的患病率和浓度。记录了研究组和对照组之间针对肺炎衣原体和巨细胞病毒的免疫球蛋白G患病率的显著差异。针对肺炎衣原体免疫球蛋白A指数不存在这种关联。研究组中所有检测抗体的血清浓度均显著高于对照组。
