Pourmand Gholamreza, Salem Sepehr, Mehrsai Abdolrasoul, Lotfi Mehrzad, Amirzargar Mohammad Ali, Mazdak Hamid, Roshani Ali, Kheirollahi Abdolreza, Kalantar Ebrahim, Baradaran Nima, Saboury Babak, Allameh Farzad, Karami Ali, Ahmadi Hamed, Jahani Yunes
Urology Research Center, Sina Hospital, Medical Sciences/University of Tehran, Hassan-Abad Sq., Tehran 1136746911, Iran.
Asian Pac J Cancer Prev. 2007 Jul-Sep;8(3):422-8.
Prostate cancer (PC), in Iran, is the third most frequently diagnosed visceral cancer among men and the seventh most common underlying cause of cancer mortality. We evaluated the relation between speculated factors and PC risk using data from a multicentric case-control study conducted in Iran from 2005 to 2007 on 130 cases of incident, clinicopathologically confirmed PC, and 75 controls admitted to the same network of hospitals without any malignant disease. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression models. The risk of PC was increased with aging (OR: 5.35, 95% CI: 2.17-13.19; P<0.0001), and with the number of sexual intercourse >or=2 times/week (OR: 3.14, 95% CI: 1.2-8.2; P=0.02). One unit elevation in serum estradiol and testosterone concentration was related to increase (OR: 1.04, 95% CI: 1.01-1.06; P=0.006) and decrease (OR: 0.79; 95% CI: 0.64-0.96; P=0.02) of PC risk, respectively. Cases were less likely to have a history of diabetes (OR: 0.34, 95% CI: 0.12-0.98; P=0.04). Increasing in dietary consumption of lycopene and fat was associated with declined (OR: 0.45, 95% CI: 0.09-2.12) and increased (OR: 2.38, 95% CI: 0.29-19.4) PC development, respectively. Other factors including educational level, marriage status, dietary meat consumption, vasectomy and smoking have not been shown to affect PC risk in the Iranian population. Our study adds further information on the potential risk factors of PC and is the first epidemiologic report from Iran. However, justification of these results requires more well-designed studies with a larger number of participants.
在伊朗，前列腺癌（PC）是男性中第三大最常被诊断出的内脏癌，也是癌症死亡的第七大常见潜在原因。我们利用2005年至2007年在伊朗进行的一项多中心病例对照研究的数据，评估了推测因素与前列腺癌风险之间的关系。该研究涉及130例新发病例、经临床病理确诊的前列腺癌患者，以及75名入住同一医院网络且无任何恶性疾病的对照者。使用条件逻辑回归模型估计比值比（OR）和相应的95%置信区间（CI）。前列腺癌风险随着年龄增长而增加（OR：5.35，95%CI：2.17 - 13.19；P<0.0001），并且随着每周性交次数≥2次而增加（OR：3.14，95%CI：1.2 - 8.2；P = 0.02）。血清雌二醇和睾酮浓度每升高一个单位，分别与前列腺癌风险增加（OR：1.04，95%CI：1.01 - 1.06；P = 0.006）和降低（OR：0.79；95%CI：0.64 - 0.96；P = 0.02）相关。病例患糖尿病的可能性较小（OR：0.34，95%CI：0.12 - 0.98；P = 0.04）。番茄红素和脂肪的饮食摄入量增加分别与前列腺癌发展减少（OR：0.45，95%CI：0.09 - 2.12）和增加（OR：2.38，95%CI：0.29 - 19.4）相关。其他因素，包括教育水平、婚姻状况、肉类饮食摄入量、输精管切除术和吸烟，在伊朗人群中未显示出会影响前列腺癌风险。我们的研究增加了关于前列腺癌潜在风险因素的更多信息，并且是来自伊朗的首份流行病学报告。然而，这些结果的合理性需要更多设计良好、参与者数量更多的研究来证实。
