Sutharama K K, Peter M C, Oommen O V
Department of Zoology, University of Kerala, Kariavattom, Trivandrum, India.
Indian J Exp Biol. 1991 Nov;29(11):1027-30.
In vivo administration of testosterone significantly stimulated the activities of cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), succinate dehydrogenase (SDH) and adenosine triphosphatase (Mg2+ ATPase), in mitochondria isolated from the liver of G. carnosus. Administration of dehydroepiandrosterone and androstenedione while significantly stimulated the activities of cytochrome oxidase and alpha-GPDH, did not change that of SDH and Mg2+ ATPase. Simultaneous injections of testosterone and actinomycin D or chloramphenicol prevented the testosterone-stimulated activities of all the oxidative enzymes studied. The results clearly document the important stimulatory role of androgens in the regulation of hepatic mitochondrial metabolism in G. carnosus.
对肉用鲈鱼肝线粒体进行体内睾酮给药，可显著刺激细胞色素氧化酶、α-甘油磷酸脱氢酶（α-GPDH）、琥珀酸脱氢酶（SDH）和腺苷三磷酸酶（Mg2+ATPase）的活性。给予脱氢表雄酮和雄烯二酮虽然显著刺激了细胞色素氧化酶和α-GPDH的活性，但并未改变SDH和Mg2+ATPase的活性。同时注射睾酮与放线菌素D或氯霉素可阻止睾酮对所有所研究氧化酶活性的刺激作用。结果清楚地证明了雄激素在调节肉用鲈鱼肝线粒体代谢中具有重要的刺激作用。
