Łukaszewicz-Zając Marta, Mroczko Barbara
Department of Biochemical Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15 a, 15-269 Bialystok, Poland.
Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
J Clin Med. 2021 May 28;10(11):2391. doi: 10.3390/jcm10112391.
The global burden of colorectal cancer (CRC) is expected to increase, with 2.2 million new cases and 1.1 million annual deaths by 2030. Therefore, the establishment of novel biomarkers useful in the early diagnosis of CRC is of utmost importance. A number of publications have documented the significance of the overexpression of several specific proteins, such as inflammatory mediators, in CRC progression. However, little is known about the potential utility of these proteins as circulating blood tumor biomarkers of CRC. Therefore, in the present review we report the results of our previous original studies as well as the findings of other authors who investigated whether inflammatory mediators might be used as novel biomarkers in the diagnosis and prognosis of CRC. Our study revealed that among all of the tested proteins, serum M-CSF, CXCL-8, IL-6 and TIMP-1 have the greatest value in the diagnosis and progression of CRC. Serum TIMP-1 is useful in differentiating between CRC and colorectal adenomas, whereas M-CSF and CRP are independent prognostic factors for the survival of patients with CRC. This review confirms the promising significance of these proteins as circulating biomarkers for CRC. However, due to their non-specific nature, further validation of their sensitivity and specificity is required.
预计到2030年，全球结直肠癌（CRC）负担将增加，新增病例达220万例，每年死亡110万例。因此，建立对CRC早期诊断有用的新型生物标志物至关重要。许多出版物都记录了几种特定蛋白质（如炎症介质）的过表达在CRC进展中的重要性。然而，对于这些蛋白质作为CRC循环血液肿瘤生物标志物的潜在用途知之甚少。因此，在本综述中，我们报告了我们之前的原创研究结果以及其他作者的研究结果，这些作者研究了炎症介质是否可用作CRC诊断和预后的新型生物标志物。我们的研究表明，在所有测试的蛋白质中，血清M-CSF、CXCL-8、IL-6和TIMP-1在CRC的诊断和进展中具有最大价值。血清TIMP-1有助于区分CRC和结直肠腺瘤，而M-CSF和CRP是CRC患者生存的独立预后因素。本综述证实了这些蛋白质作为CRC循环生物标志物的潜在重要意义。然而，由于其非特异性性质，需要进一步验证其敏感性和特异性。
