Arunakaran J, Aruldhas M M, Govindarajulu P
Department of Endocrinology, University of Madras, Taramani.
Indian J Physiol Pharmacol. 1987 Jul-Sep;31(3):184-9.
The effect of castration and administration of testosterone propionate (TP) has been studied in mature monkeys in relation to prostatic and seminal vesicular lipids to castrates on prostatic and seminal vesicular lipids were studied in mature monkeys. Castration decreased prostatic total lipid, total phospholipids and total glyceride glycerols. Among neutral lipid classes only diacyl glycerol was decreased due to castration. Similarly among phospholipid classes, phosphatidyl choline and ethanolamine were decreased. A marked decrease in the seminal vesicular total lipid, total phospholipids, total cholesterol and total glyceride glycerol were observed due to castration. Mono and diacyl glycerols and phosphatidyl choline and ethanolamine also registered a significant decrease after castration. Administration of TP to castrates brought back all the lipid classes to normal level which showed a decrease due to castration. However, TP treated to castrates on both seminal vesicles and prostates had no effect on other classes of lipids which were unaltered by castration. The present study reveals that lipid metabolism in the male accessory sex organs is under androgenic control. Nevertheless, the influence of testicular androgen is specific to different classes of lipids as a number of phospholipids and neutral lipid classes were resistant to castration or administration of TP.
在成年猴子中研究了去势和给予丙酸睾酮（TP）对前列腺和精囊脂质的影响。在成年猴子中研究了去势对前列腺和精囊脂质的影响。去势降低了前列腺总脂质、总磷脂和总甘油酯甘油。在中性脂质类别中，只有二酰甘油因去势而减少。同样，在磷脂类别中，磷脂酰胆碱和乙醇胺减少。观察到去势导致精囊总脂质、总磷脂、总胆固醇和总甘油酯甘油显著减少。单酰甘油和二酰甘油以及磷脂酰胆碱和乙醇胺在去势后也显著减少。给去势动物给予TP使所有脂质类别恢复到因去势而降低的正常水平。然而，对精囊和前列腺的去势动物给予TP对其他未因去势而改变的脂质类别没有影响。本研究表明，雄性附属生殖器官中的脂质代谢受雄激素控制。然而，睾丸雄激素的影响对不同类别的脂质具有特异性，因为许多磷脂和中性脂质类别对去势或给予TP具有抗性。
