Qiao Hong-Xiang, Liu Yong-Ye, Wu Li-Mao, Li Lian-Da
Institute of Chinese Herb Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhongguo Zhong Yao Za Zhi. 2007 Oct;32(19):2048-51.
To evaluate the toxicity of Radix Aristolochiae and Radix Inulae, and to supply the toxicity experimental data that Radix Inulae supersedes Radix Aristolochiae in clinic.
A long dose of Radix Aristolochice and Radix Inulae was given intragastrically to rats for six months, then drug withdrawal for a month. The hematology and biochemical indicators were measured, and the pathologic changes of kidney, liver, stomach and urinary bladder were examined.
The rats of Radix Aristolochice showed serious toxic responses of renal tubule atrophy and necrosis, meanwhile, the levels of BUN, Cr and NAG were increased obviously. Hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered with pathologic assaying. But the rats of Radix Inulae did not.
Radix Aristolochiae could damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity. Radix Inulae could take the place of Radix Aristolochiae to use in clinic.
评价马兜铃根和旋覆花根的毒性，为旋覆花根在临床上替代马兜铃根提供毒性实验数据。
对大鼠灌胃给予长期大剂量的马兜铃根和旋覆花根，持续6个月，然后停药1个月。检测血液学和生化指标，并检查肾脏、肝脏、胃和膀胱的病理变化。
马兜铃根组大鼠出现肾小管萎缩和坏死等严重毒性反应，同时血尿素氮（BUN）、肌酐（Cr）和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）水平明显升高。病理检测发现肝坏死、肾小管坏死、胃癌和膀胱癌。但旋覆花根组大鼠未出现上述情况。
马兜铃根毒性较强，可损害肾脏和肝脏，并导致胃癌和膀胱癌。旋覆花根可在临床上替代马兜铃根使用。
