Honkonen Teija I, Aro Timo A, Isometsä Erkki T, Virtanen E Marianna, Katila Heikki O
Finnish Institute of Occupational Health, Helsinki, Finland.
J Clin Psychiatry. 2007 Dec;68(12):1886-93. doi: 10.4088/jcp.v68n1208.
Depressive disorders cause substantial work impairment that can lead to disability compensation. The authors compared treatment received for depression preceding disability pension between 2 nationally representative samples with a 10-year interval.
The medical statements for 2 random samples drawn from the Finnish national disability pension registers, representing populations granted a disability pension for DSM-III-R major depression during a 12-month period from October 1993 through September 1994 (N = 277) and for ICD-10 depressive disorders (F32-F33) from October 2003 through September 2004 (N = 265) were examined. The proportions of persons receiving weekly psychotherapy, antidepressants, adequate antidepressant dosage, sequential antidepressant trials, lithium augmentation, and electroconvulsive therapy (ECT) were compared.
No significant differences emerged between the 2 samples, except for the adequacy of antidepressant dosage. Few subjects in either of the samples (8.7% for 1993-1994 vs. 10.6% for 2003-2004, p = .45) had received weekly psychotherapy. Most had received antidepressants (87.4% vs. 85.6%, p = .55) with increasingly adequate dosage (75.6% vs. 85.0%, p = .02), but only a minority had received sequential antidepressant trials (39.5% vs. 44.5%, p = .24). Lithium augmentation and ECT were rare (1.1% vs. 1.5%, p = .66 and 4.0% vs. 1.5%, p = .08, respectively). Even in 2003-2004, over half of the subjects were granted a disability pension without sequential antidepressant trials.
This nationally representative study indicates that, despite an increased antidepressant use and improved practice guidelines for depression, a considerable proportion of the people granted long-term compensation for depression seem to be suboptimally treated. Given the enormous costs of the disability, attention to the quality of treatment provided for depression is warranted before long-term disability compensations are granted.
抑郁症会导致严重的工作能力受损,进而可能导致残疾抚恤金的发放。作者比较了两个具有全国代表性的样本在间隔10年时间里,在领取残疾抚恤金之前针对抑郁症所接受的治疗情况。
对从芬兰国家残疾抚恤金登记册中抽取的两个随机样本的医疗声明进行了检查。一个样本代表1993年10月至1994年9月这12个月期间因DSM-III-R重度抑郁症而获得残疾抚恤金的人群(N = 277),另一个样本代表2003年10月至2004年9月因ICD-10抑郁症(F32 - F33)而获得残疾抚恤金的人群(N = 265)。比较了接受每周心理治疗、抗抑郁药治疗、足够抗抑郁药剂量治疗、序贯抗抑郁药试验、锂盐增效治疗和电休克治疗(ECT)的患者比例。
除了抗抑郁药剂量的充足性外,两个样本之间没有出现显著差异。两个样本中很少有受试者接受每周心理治疗(1993 - 1994年为8.7%,2003 - 2004年为10.6%,p = 0.45)。大多数人接受了抗抑郁药治疗(87.4%对85.6%,p = 0.55),且剂量充足的比例有所增加(75.6%对85.0%,p = 0.02),但只有少数人接受了序贯抗抑郁药试验(39.5%对44.5%,p = 0.24)。锂盐增效治疗和ECT很少见(分别为1.1%对1.5%,p = 0.66和4.0%对1.5%,p = 0.08)。即使在2003 - 2004年,超过一半的受试者在没有进行序贯抗抑郁药试验的情况下就获得了残疾抚恤金。
这项具有全国代表性的研究表明,尽管抗抑郁药的使用有所增加,且抑郁症的治疗指南有所改进,但相当一部分获得抑郁症长期补偿的人似乎没有得到最佳治疗。鉴于残疾的巨大成本,在发放长期残疾补偿之前,有必要关注为抑郁症患者提供的治疗质量。