来自海洋海绵Ircinia sp.的多盘酰胺B-D，作为有效的人类感觉神经元特异性G蛋白偶联受体激动剂。

Polydiscamides B-D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists.

作者信息

Feng Yunjiang, Carroll Anthony R, Pass David M, Archbold Julia K, Avery Vicky M, Quinn Ronald J

机构信息

Eskitis Institute, Griffith University, Brisbane, Queensland, Australia.

出版信息

J Nat Prod. 2008 Jan;71(1):8-11. doi: 10.1021/np070094r. Epub 2007 Dec 29.

DOI:10.1021/np070094r

PMID:18163586

Abstract

Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.

摘要

从海绵Ircinia sp.中分离出了多盘酰胺B、C和D（1-3）。通过将它们的核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）光谱数据与结构相关化合物多盘酰胺A的数据进行比较，阐明了1至3的结构。所有化合物对人类感觉神经元特异性G蛋白偶联受体（SNSR，一种参与疼痛调节的受体）均表现出强效激动剂活性，并且它们是非内源性人类SNSR激动剂的首个实例。