来自巴布亚新几内亚植物大瓣 Cupaniopsis 的 Pim2 抑制剂。

Pim2 inhibitors from the Papua New Guinean plant Cupaniopsis macropetala.

作者信息

Davis Rohan A, Simpson Moana M, Nugent Ryan B, Carroll Anthony R, Avery Vicky M, Rali Topul, Chen Huawei, Qurallo Barbara, Quinn Ronald J

机构信息

Eskitis Institute, Griffith University, Brisbane, Australia.

出版信息

J Nat Prod. 2008 Mar;71(3):451-2. doi: 10.1021/np070431w. Epub 2007 Dec 29.

DOI:10.1021/np070431w

PMID:18163587

Abstract

Bioassay-guided fractionation of an organic extract from the leaves of Cupaniopsis macropetala resulted in the isolation of a new alkaloid, galloyl tyramine ( 1), together with the known flavonoid glycoside quercitrin ( 2). The structure of 1 was determined following 1D and 2D NMR, IR, UV, and MS data analysis. Compounds 1 and 2 displayed IC 50 values of 161 and 25 microM, respectively, in a Pim2 enzyme assay.

摘要

对大瓣卡帕木（Cupaniopsis macropetala）叶的有机提取物进行生物测定导向的分级分离，得到了一种新的生物碱——没食子酰酪胺（1），以及已知的黄酮苷槲皮苷（2）。通过一维和二维核磁共振、红外光谱、紫外光谱和质谱数据分析确定了1的结构。在Pim2酶测定中，化合物1和2的IC50值分别为161和25微摩尔。