藤黄双异戊烯基苯甲酮O和P，来自所罗门藤黄的异戊烯基化二苯甲酮类丝裂原活化蛋白激酶激活的蛋白激酶-2抑制剂
Guttiferones O and P, prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis.
作者信息
Carroll Anthony R, Suraweera Lekha, King Gordon, Rali Topul, Quinn Ronald J
机构信息
Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
出版信息
J Nat Prod. 2009 Sep;72(9):1699-701. doi: 10.1021/np900246t.
Two prenylated benzophenones, guttiferones O (1) and P (2), were isolated from the stem bark of the Papua New Guinean plant Garcina solomonensis. The structures of these compounds and their relative configurations were determined by spectroscopic methods. Both compounds inhibited the phosphorylation of the synthetic biotinylated peptide substrate KKLNRTLSVA by the serine/threonine protein kinase MAPKAPK-2 with IC(50) values of 22.0 microM.
从巴布亚新几内亚植物所罗门山竹子（Garcina solomonensis）的茎皮中分离出两种异戊烯基化二苯甲酮，藤黄酮O（1）和藤黄酮P（2）。通过光谱方法确定了这些化合物的结构及其相对构型。这两种化合物均能抑制丝氨酸/苏氨酸蛋白激酶MAPKAPK-2对合成生物素化肽底物KKLNRTLSVA的磷酸化作用，IC50值为22.0微摩尔。
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