Krueger Ronald R, Thornton Ivey L, Xu Meng, Bor Zsolt, van den Berg Thomas J T P
Department of Refractive Surgery, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Ophthalmology. 2008 Jul;115(7):1187-1195.e1. doi: 10.1016/j.ophtha.2007.10.007. Epub 2007 Dec 27.
To report a new optical side effect associated with the IntraLASIK procedure.
Retrospective chart review and questionnaire of all patients treated with IntraLASIK from June 2004 to August 2005.
A cohort of 585 eyes (312 patients) was divided sequentially into those treated with the older-model IntraLase laser (group 1: 399 eyes of 215 patients) and those treated with the newer model (group 2: 186 eyes of 97 patients).
Preoperative and postoperative refraction, visual acuity, pupillometry, pachymetry, intraocular pressure, mean topographic power and cylinder, wavefront aberrations, and answers to a questionnaire of symptoms were recorded. The precise spatial extent of the rainbow spectrum was drawn by select patients for calculation of the diffractive grating size responsible for the light scatter. A glass slide was also irradiated and photographed using the older model to simulate the rainbow spectrum.
The symptom of rainbow glare was correlated with preoperative and postoperative factors and time between the most recent service call and surgery.
In group 1, 90.2% of patients were successfully contacted, and 37 (69 eyes) reported symptoms of rainbow glare around lights, for an incidence of 19.07%. In group 2, 88.6% of patients were contacted, and 2 (4 eyes) reported similar symptoms, for an incidence of 2.32%. The odds ratio (OR) between the 2 groups is 9.4 (P<0.001). For every 10-mum increase in ablation depth, the OR is 1.2 (P = 0.038), and for every 30 days from the last service call, it is 1.5 (P = 0.007). The spatial extent of the color pattern was used to calculate the spacing array at approximately 9 mum, corresponding to the laser spot and line separation.
Light scattering from the back surface of the IntraLASIK flap creates a spectral pattern whose visual impact is clinically inconsequential in the majority of patients. The spectral pattern and visual angle correspond to a grating size that matches the raster spot separation of IntraLase pulsing. Eyes treated with newer focusing optics of higher numerical aperture reduced the rainbow symptom. Variance in optical quality and numerical aperture can impact the spot size and uniformity of IntraLase flap creation.
报告准分子原位角膜磨镶术(IntraLASIK)相关的一种新的光学副作用。
对2004年6月至2005年8月期间接受IntraLASIK治疗的所有患者进行回顾性病历审查和问卷调查。
一组585只眼(312例患者)依次分为接受旧型号IntraLase激光治疗的患者(第1组:215例患者的399只眼)和接受新型号治疗的患者(第2组:97例患者的186只眼)。
记录术前和术后的屈光、视力、瞳孔测量、角膜厚度测量、眼压、平均地形图屈光力和柱镜、波前像差以及症状问卷的答案。部分患者绘制了彩虹光谱的精确空间范围,以计算导致光散射的衍射光栅大小。还使用旧型号对载玻片进行照射并拍照,以模拟彩虹光谱。
彩虹眩光症状与术前和术后因素以及最近一次维修呼叫与手术之间的时间相关。
在第1组中,成功联系到90.2%的患者,37例(69只眼)报告有灯光周围彩虹眩光症状,发生率为19.07%。在第2组中,联系到88.6%的患者,2例(4只眼)报告有类似症状,发生率为2.32%。两组之间的优势比(OR)为9.4(P<0.001)。消融深度每增加10μm,OR为1.2(P = 0.038),自上次维修呼叫起每30天,OR为1.5(P = 0.007)。利用颜色图案的空间范围计算出间距阵列约为9μm,对应于激光光斑和线条间距。
IntraLASIK角膜瓣后表面的光散射产生一种光谱图案,其视觉影响在大多数患者中临床上并不重要。光谱图案和视角对应于与IntraLase脉冲的光栅光斑间距相匹配的光栅大小。采用更高数值孔径的新型聚焦光学系统治疗的眼睛减少了彩虹症状。光学质量和数值孔径的差异会影响IntraLase角膜瓣制作的光斑大小和均匀性。