小檗碱可预防紫外线诱导的人皮肤成纤维细胞中基质金属蛋白酶-1的产生及I型前胶原表达的减少。
Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts.
作者信息
Kim Sangmin, Chung Jin Ho
机构信息
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
出版信息
Phytomedicine. 2008 Sep;15(9):749-53. doi: 10.1016/j.phymed.2007.11.004. Epub 2007 Dec 27.
Matrix metalloproteinases (MMPs) induction and type I procollagen reduction in photoaging of the skin due to exposure to ultraviolet (UV) irradiation. Therefore, regulation of these genes has been suggested to be a useful tool to abolish skin aging. In this study, antioxidative plant ingredients used in traditional Chinese medicine, berberine (BBR) was investigated for their capacity to regulate MMP-1 and type I procollagen expression in human dermal fibroblasts. Our results showed that both basal and UV-induced MMP-1 expression was decreased by BBR. On the other hand, type I procollagen expression was dose-dependently increased by it. In addition, UV-induced reduction of type I procollagen expression is recovered by it. Therefore, we suggest that BBR may be a possible candidate for anti-skin aging agent.
由于暴露于紫外线（UV）辐射，基质金属蛋白酶（MMPs）在皮肤光老化中被诱导，而I型前胶原减少。因此，调节这些基因被认为是消除皮肤老化的一种有用工具。在本研究中，对传统中药中使用的抗氧化植物成分黄连素（BBR）调节人皮肤成纤维细胞中MMP-1和I型前胶原表达的能力进行了研究。我们的结果表明，BBR可降低基础和UV诱导的MMP-1表达。另一方面，I型前胶原表达则呈剂量依赖性增加。此外，它还能恢复UV诱导的I型前胶原表达的降低。因此，我们认为BBR可能是一种抗皮肤老化剂的潜在候选物。
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