Kim Hoon, Park Soon Yeong, Chung Dae Kyun
Skin-Biotechnology Center, Kyung Hee University, Gwanggyo-ro 147, Yeongtong-gu, Suwon 16229, Korea.
Dain Natural Co., Ltd. 130-33, Gasong-ro, Pungse-myeon, Dongnam-gu, Cheonan 31216, Korea.
Pharmaceuticals (Basel). 2021 Mar 6;14(3):222. doi: 10.3390/ph14030222.
Most of the studies on common evening primrose ( L.) are focused on its oils (isolated from seed, root, and stem tissues). We aimed to investigate the effect of the oral administration of OBS-E on the improvement of skin function in skin-damaged hairless mice exposed to excessive ultraviolet B (UVB) radiation owing to the preliminary in vitro findings regarding the antioxidant, anti-wrinkle, and skin moisturizing activities of OBS-E. OBS-E administration for 14 weeks did not significantly affect the body weight or clinical signs. Significant reductions were observed in wrinkle parameters (area, number, length, and depth, and metalloproteinase levels) in OBS-E-administered mice compared with those in UVB-irradiated control mice. OBS-E significantly increased skin elasticity and hyaluronic acid content, but it significantly decreased transepidermal water loss. Histomorphometrical analysis revealed that OBS-E significantly reduced the epidermal thickness, area of the collagen-occupied region, and number of microfolds and inflammatory and mast cells. These results demonstrate that OBS-E can effectively enhance skin functions in terms of ameliorating wrinkle formation, promoting skin-moisturization, enhancing skin barrier function, and inhibiting inflammatory reactions. The obtained results provide good starting point for the continuation in the process of developing new inner beauty products based on OBS-E.
大多数关于月见草（L.）的研究都集中在其油类（从种子、根和茎组织中分离出来）。鉴于月见草油提取物（OBS-E）在抗氧化、抗皱和皮肤保湿活性方面的初步体外研究结果，我们旨在研究口服OBS-E对因过度紫外线B（UVB）辐射而皮肤受损的无毛小鼠皮肤功能改善的影响。给予OBS-E 14周对体重或临床体征没有显著影响。与紫外线B照射的对照小鼠相比，给予OBS-E的小鼠的皱纹参数（面积、数量、长度和深度以及金属蛋白酶水平）显著降低。OBS-E显著增加了皮肤弹性和透明质酸含量，但显著降低了经表皮水分流失。组织形态计量学分析表明，OBS-E显著降低了表皮厚度、胶原占据区域的面积、微褶皱以及炎症细胞和肥大细胞的数量。这些结果表明，OBS-E在改善皱纹形成、促进皮肤保湿、增强皮肤屏障功能和抑制炎症反应方面可以有效增强皮肤功能。所获得的结果为基于OBS-E开发新的内在美产品的后续研究提供了良好的起点。
