Nocito Ana Lia, Sarancone Sandra, Bacchi Carlos, Tellez Tomás
Pathology Department, School of Medicine, Universidad Nacional de Rosario, 2000 Argentina.
Ann Diagn Pathol. 2008 Feb;12(1):12-6. doi: 10.1016/j.anndiagpath.2007.01.011. Epub 2007 Oct 3.
The clinicopathological findings of 50 thecoma cases were studied to establish the most useful diagnostic criteria helpful in characterizing this ovarian stromal tumor. Patient age ranged from 21 to 77 years (median, 57.5 years). In this study, thecoma appears to be associated with endometrial diseases (15 patients) as an incidental finding in a gynecologic routine examination (14 patients) and in a cesarean delivery (1 patient). Arteries, veins, lymphatics, and mast cells are normally present in the ovarian medulla and are absent in the cortical area. The 50 thecomas studied showed proliferation of stromal cells and presence of arteries, lymphatics, and mast cells. Thecoma tumoral growth appeared to cause atrophy or compression of the cortical area. These findings are significant for diagnosis; thus, thecoma is proposed as a tumor originating in the ovarian medulla. Fibroma and thecoma seem to be different neoplasms and should be considered distinct, separate entities because they have different origin, morphology, and potential functionality.
对50例卵泡膜细胞瘤的临床病理特征进行研究，以确立有助于诊断这种卵巢间质肿瘤的最有用的诊断标准。患者年龄为21至77岁（中位数为57.5岁）。在本研究中，卵泡膜细胞瘤似乎与子宫内膜疾病相关（15例患者），在妇科常规检查中偶然发现（14例患者），在剖宫产中发现1例。动脉、静脉、淋巴管和肥大细胞通常存在于卵巢髓质中，而皮质区域不存在。所研究的50例卵泡膜细胞瘤显示间质细胞增生以及动脉、淋巴管和肥大细胞的存在。卵泡膜细胞瘤的肿瘤生长似乎导致皮质区域萎缩或受压。这些发现对诊断具有重要意义；因此，卵泡膜细胞瘤被认为是起源于卵巢髓质的肿瘤。纤维瘤和卵泡膜细胞瘤似乎是不同的肿瘤，应被视为不同的独立实体，因为它们具有不同的起源、形态和潜在功能。
