Larson Paul Sloan
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA.
Neurotherapeutics. 2008 Jan;5(1):50-8. doi: 10.1016/j.nurt.2007.11.006.
Surgery for psychiatric disorders first began in the early part of the last century when the therapeutic options for these patients were limited. The introduction of deep brain stimulation (DBS) has caused a new interest in the surgical treatment of these disorders. DBS may have some advantage over lesioning procedures used in the past. A critical review of the major DBS targets under investigation for Tourette's syndrome, obsessive-compulsive disorder, and major depression is presented. Current and future challenges for the use of DBS in psychiatric disorders are discussed, as well as a rationale for referring to this subspecialty as limbic disorders surgery based on the parallels with movement disorders surgery.
精神疾病的外科治疗始于上世纪初，当时针对这些患者的治疗选择有限。深部脑刺激（DBS）的引入引发了对这些疾病外科治疗的新兴趣。DBS可能比过去使用的毁损手术有一些优势。本文对正在研究的用于治疗妥瑞氏症、强迫症和重度抑郁症的主要DBS靶点进行了批判性综述。讨论了DBS在精神疾病应用中的当前和未来挑战，以及基于与运动障碍手术的相似性将这一亚专业称为边缘系统疾病手术的基本原理。
