van Peer Jacobien M, Roelofs Karin, Spinhoven Philip
Department of Clinical, Health and Neuropsychology, Leiden University, PO Box 9555, 2300 RB Leiden, The Netherlands.
Int J Psychophysiol. 2008 Feb;67(2):144-50. doi: 10.1016/j.ijpsycho.2007.11.001. Epub 2007 Nov 22.
There is increasing evidence that the strength of the relation between slow (SW) and fast (FW) wave activity in the EEG is associated with specific motivational states and their corresponding neuroendocrine patterns. Enhanced correlations between SW and FW have been related to anxiety, behavioral inhibition and high basal cortisol levels. However, the direct effects of cortisol on SW-FW coupling have not been experimentally studied yet. The present study investigated whether cortisol administration increases SW-FW coupling. Resting state EEG recordings were obtained from 40 right-handed healthy male subjects with extreme low or high scores on a behavioral inhibition scale, after placebo and cortisol (50 mg) administration. As expected, cortisol resulted in a significant increase in correlation between SW (delta) and FW (beta) activity compared to placebo. In addition, delta-beta correlation was significantly higher in high compared to low behaviorally inhibited subjects in both conditions. These results suggest that cortisol can modify brain activity, increasing a pattern associated with anxiety and behavioral inhibition. This is in line with findings associating cortisol with behavioral inhibition and anxiety.
越来越多的证据表明，脑电图中慢波（SW）和快波（FW）活动之间关系的强度与特定的动机状态及其相应的神经内分泌模式有关。SW和FW之间增强的相关性与焦虑、行为抑制和高基础皮质醇水平有关。然而，皮质醇对SW-FW耦合的直接影响尚未进行实验研究。本研究调查了给予皮质醇是否会增加SW-FW耦合。在给予安慰剂和皮质醇（50毫克）后，从40名行为抑制量表得分极低或极高的右利手健康男性受试者身上获取静息状态脑电图记录。正如预期的那样，与安慰剂相比，皮质醇导致SW（δ波）和FW（β波）活动之间的相关性显著增加。此外，在两种情况下，行为抑制程度高的受试者的δ-β相关性显著高于行为抑制程度低的受试者。这些结果表明，皮质醇可以改变大脑活动，增加与焦虑和行为抑制相关的模式。这与将皮质醇与行为抑制和焦虑联系起来的研究结果一致。
