Nikulina E M
Institute of Cytology and Genetics, Siberian Branch of Academy of Sciences, Novosibirsk, USSR.
Neurosci Biobehav Rev. 1991 Winter;15(4):545-7. doi: 10.1016/s0149-7634(05)80146-0.
The neural mechanisms of predatory aggression in laboratory animals were investigated in a variety of rodents and members of the order Carnivora. Experimental enhancement of brain serotonin (5-HT) blocked killing behavior in rats, mice, mink and silver foxes, indicating that there is a 5-HT inhibiting mechanism of predatory aggression in animals of different species. Suppressed killing behavior, at least in some strains of mice, does not depend for expression on the inhibitory effect of the brain 5-HT system, but is caused by the low tonus of the system activating predatory behavior. Long-term satiation of mink increased the level of 5-hydroxyindole acetic acid in the lateral hypothalamus and amygdala and enhanced the latency of predatory aggression. It is suggested that 5-HT represents a dietary responsive endogenous factor regulating predatory behavior in carnivores. Selection of Norway rats over many generations for tamed behavior towards man (domestication) leads to an increase in level and turnover of 5-HT in the midbrain and hypothalamus, but does not change predatory aggression. Substantially reduced defensive behavior of domesticated rats is thus unconnected with the neural mechanism of predatory aggression.
在各种啮齿动物和食肉目动物中研究了实验动物捕食性攻击的神经机制。实验性增强脑血清素（5-羟色胺，5-HT）可阻断大鼠、小鼠、水貂和银狐的杀戮行为，这表明在不同物种的动物中存在5-HT对捕食性攻击的抑制机制。至少在某些品系的小鼠中，杀戮行为的抑制并不依赖于脑5-HT系统的抑制作用，而是由激活捕食行为的该系统的低紧张度引起的。长期给水貂喂食可增加下丘脑外侧和杏仁核中5-羟吲哚乙酸的水平，并延长捕食性攻击的潜伏期。有人提出，5-HT是调节食肉动物捕食行为的一种饮食反应性内源性因子。经过多代选择挪威大鼠使其对人表现出温顺行为（驯化），导致中脑和下丘脑中5-HT的水平和周转率增加，但不改变捕食性攻击行为。因此，驯化大鼠防御行为的大幅减少与捕食性攻击的神经机制无关。
