Perkins A N, Eckerman D A, MacPhail R C
Department of Psychology, University of North Carolina, Chapel Hill 27599.
Pharmacol Biochem Behav. 1991 Dec;40(4):757-61. doi: 10.1016/0091-3057(91)90081-c.
Two groups of rats (N = 4 each) were trained to discriminate either triadimefon (40 mg/kg) or methylphenidate (4 mg/kg) from saline in a two-lever, milk-reinforced drug discrimination paradigm. Dose-response functions were determined during 5-min extinction sessions. Both agents produced a dose-related increase in the percentage of responses that occurred on the drug lever. In the substitution phase of the study, rats trained to discriminate triadimefon were tested with methylphenidate and rats trained to discriminate methylphenidate were tested with triadimefon. Triadimefon substituted completely for methylphenidate and methylphenidate substituted completely for triadimefon. These results indicate that triadimefon can function as a discriminative stimulus and that it shares discriminative stimulus properties with methylphenidate.
两组大鼠（每组N = 4）在双杠杆、牛奶强化的药物辨别范式中接受训练，以区分三唑酮（40毫克/千克）或哌甲酯（4毫克/千克）与生理盐水。在5分钟的消退实验中确定剂量反应函数。两种药物均使药物杠杆上的反应百分比出现与剂量相关的增加。在研究的替代阶段，训练区分三唑酮的大鼠用哌甲酯进行测试，训练区分哌甲酯的大鼠用三唑酮进行测试。三唑酮完全替代了哌甲酯，哌甲酯也完全替代了三唑酮。这些结果表明，三唑酮可以作为一种辨别性刺激，并且它与哌甲酯具有共同的辨别性刺激特性。
