Iezzi Giovanna, Scarano Antonio, Mangano Carlo, Cirotti Bruno, Piattelli Adriano
Dental School, University of Chieti-Pescara, Chieti, Italy.
J Periodontol. 2008 Jan;79(1):192-8. doi: 10.1902/jop.2008.070105.
Little is known about the healing pattern and the osseointegration processes at the interface of implants placed into different grafting materials in man. Anorganic bovine bone (ABB) is a xenogenic material with a high biocompatibility and osteoconductivity.
A 47-year-old patient underwent a monolateral sinus-augmentation procedure using 100% ABB. Two titanium dental implants were inserted at the same time as the grafting procedure. After 6 months, a fixed prosthetic restoration was placed. After a 5-year loading period, the distal implant fractured, and the implant was removed with a 5-mm trephine bur.
At low magnification, in the peri-implant bone in the grafted area, many particles of ABB were still present. Bone was always interposed between the ABB particles and the metal surface, and in no case were the graft particles in contact with the implant. No acute or chronic inflammatory cell infiltrate or foreign body reactions were present around the particles or at the bone-implant interface. The tissues around the implant were composed of 40% +/- 2.4% bone, 12% +/- 2.9% ABB particles, and 50% +/- 6.2% marrow spaces. The percentage of bone-to-implant contact was 48.6% +/- 3.7%.
A high percentage (~50%) of direct contact between bone and implant, without the interposition of graft material particles, was present. ABB had enabled implant integration to take place, which had remained stable for 5 years.
对于植入人体不同移植材料中的种植体界面的愈合模式和骨结合过程，人们了解甚少。无机牛骨（ABB）是一种具有高生物相容性和骨传导性的异种材料。
一名47岁患者接受了使用100% ABB的单侧窦底提升手术。在移植手术的同时植入了两颗钛牙种植体。6个月后，进行了固定义齿修复。经过5年的加载期后，远端种植体发生骨折，使用5毫米环钻将种植体取出。
在低倍镜下，在移植区域的种植体周围骨组织中，仍存在许多ABB颗粒。骨组织总是介于ABB颗粒与金属表面之间，移植颗粒在任何情况下都未与种植体接触。在颗粒周围或骨-种植体界面处未出现急性或慢性炎性细胞浸润或异物反应。种植体周围组织由40%±2.4%的骨组织、12%±2.9%的ABB颗粒和50%±6.2%的骨髓腔组成。骨与种植体的接触百分比为48.6%±3.7%。
骨与种植体之间存在高比例（约50%）的直接接触，中间没有移植材料颗粒的介入。ABB促成了种植体的整合，并且这种整合在5年内保持稳定。
