Lin R C
Shandong Institute of Industrial Hygiene and Occupational Diseases, Ji'nan.
Zhonghua Yu Fang Yi Xue Za Zhi. 1991 Nov;25(6):356-8.
beta 2-microglobulin (beta 2-M), albumin (Alb), IgG, Protein in urine were measured in 59 workers exposed to toluene, and xylene, and 70 workers not so exposed as control. The results showed that the urine levels of beta 2-M, Alb in exposed groups were significantly higher and increased progressively with increasing work time. Urinary beta 2-M showed significantly positive correlation with Alb, protein. Conformability of beta 2-M, Alb with other renal damage indexes seems better. It is suggested that toluene and xylene might cause renal damage, changes of urinary beta 2-M and Alb concentrations might be used as sensitive indexes for early detection of renal dysfunction in toluene and xylene workers.
对59名接触甲苯和二甲苯的工人以及70名未接触的工人作为对照，检测其尿β2-微球蛋白（β2-M）、白蛋白（Alb）、免疫球蛋白G（IgG）和尿蛋白。结果显示，接触组尿β2-M、Alb水平显著升高，并随工作时间延长而逐渐增加。尿β2-M与Alb、蛋白呈显著正相关。β2-M、Alb与其他肾损伤指标的符合度似乎更好。提示甲苯和二甲苯可能导致肾损伤，尿β2-M和Alb浓度变化可作为甲苯和二甲苯接触工人早期肾功能损害的敏感指标。
