Goldstein D P, Goldstein P R, Bottomley P, Osathanondh R, Marean A R
Obstet Gynecol. 1976 Sep;48(3):321-3.
Fifteen patients with nonmetastatic gestational trophoblastic neoplasms were treated primarily with methotrexate and citrovorum factor. Complete and sustained remission was achieved in 14 of the 15 patients. Response to treatment was determined solely on the basis of serial serum human chorionic gonadotropin levels as measured by the beta subunit radioimmunoassay. All patients developed nonmetastatic gestational trophoblastic neoplasms following evacuation of a molar pregnancy. The known histologic diagnosis in all cases was hydatidiform mole. No significant toxicity was encountered despite careful monitoring of marrow, hepatic, renal, neurologic, and mucocutaneous parameters. Up to January 31, 1976, duration of remission ranged from 2 to 14 months.
15例非转移性妊娠滋养细胞肿瘤患者主要接受甲氨蝶呤和亚叶酸治疗。15例患者中有14例实现了完全且持续的缓解。治疗反应仅根据通过β亚单位放射免疫测定法测量的系列血清人绒毛膜促性腺激素水平来确定。所有患者在葡萄胎排空后均发生非转移性妊娠滋养细胞肿瘤。所有病例已知的组织学诊断均为葡萄胎。尽管对骨髓、肝脏、肾脏、神经和皮肤黏膜参数进行了仔细监测，但未发现明显毒性。截至1976年1月31日，缓解期为2至14个月。
