Goldstein D P, Saracco P, Osathanondh R, Goldstein P R, Marean A R, Bernstein M R
Obstet Gynecol. 1978 Jan;51(1):93-6.
Thirty-five patients with nometastatic gestational trophoblastic neoplasms and 3 patients with metastatic gestational trophoblastic neoplasms were treated primarily with methotrexate and citrovorum factor rescue. The antecedent pregnancy was molar in all patients. The known histologic diagnosis in 34 patients was hydatdiform mole and choriocarcinoma in 3. Up to March 1977, the duration of remissions ranged from 1 to 21 months. Complete and sustained remission was achieved in 91% of patients with nonmetastatic disease and in 2 of the 3 patients with metastases, without evidence of marrow or hepatic and with substantially reduced epithelial toxicity. Response to treatment and the number of courses required to achieve remission were determined solely on the basis of the human chorionic gonadotropin response as measured by the beta subunit radioimmunoassay.
35例无转移的妊娠滋养细胞肿瘤患者和3例有转移的妊娠滋养细胞肿瘤患者主要接受甲氨蝶呤及亚叶酸解救治疗。所有患者的前次妊娠均为葡萄胎。34例患者已知的组织学诊断为葡萄胎，3例为绒毛膜癌。至1977年3月，缓解期持续1至21个月。91%的无转移疾病患者及3例有转移患者中的2例实现了完全且持续的缓解，无骨髓、肝脏受累迹象，上皮毒性显著降低。治疗反应及达到缓解所需的疗程数仅根据通过β亚基放射免疫测定法测得的人绒毛膜促性腺激素反应来确定。
