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利奈唑胺与哌替啶联合治疗后出现血清素综合征。

Serotonin syndrome after concomitant treatment with linezolid and meperidine.

作者信息

Das Prabodh K, Warkentin Dawn I, Hewko Robert, Forrest Donna L

机构信息

Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

出版信息

Clin Infect Dis. 2008 Jan 15;46(2):264-5. doi: 10.1086/524671.

DOI:10.1086/524671
PMID:18171260
Abstract

Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors. Meperidine blocks the neuronal reuptake of serotonin. Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described. We describe serotonin syndrome after concomitant use of linezolid and meperidine in a 27-year-old man with acute leukemia.

摘要

已有报道称，使用利奈唑胺和5-羟色胺再摄取抑制剂会引发5-羟色胺综合征。哌替啶会阻碍5-羟色胺的神经元再摄取。利奈唑胺和哌替啶联合治疗后出现5-羟色胺综合征的情况尚未见报道。我们描述了一名27岁急性白血病男性患者在同时使用利奈唑胺和哌替啶后发生5-羟色胺综合征的病例。

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Serotonin syndrome after concomitant treatment with linezolid and meperidine.利奈唑胺与哌替啶联合治疗后出现血清素综合征。
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