Milstone Aaron M, Passaretti Catherine L, Perl Trish M
Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Clin Infect Dis. 2008 Jan 15;46(2):274-81. doi: 10.1086/524736.
Health care-associated infections (HAIs) result in increased patient morbidity and utilization of health care resources. Rates of HAI are increasing despite advances in health care technology. Limited antimicrobial agents and a dry drug pipeline make novel prevention efforts critical. Chlorhexidine, an antiseptic solution that has been used worldwide since the 1950s, is a safe and effective product with broad antiseptic activity. Novel uses of chlorhexidine-containing products are being implemented to promote antisepsis and prevent bacterial colonization and infection. We review some of the many infection control applications of chlorhexidine in the battle against HAI, such as general skin cleansing, skin decolonization, preoperative showering and bathing, vascular catheter site preparation, impregnated catheter site dressings, impregnated catheters, and oral decontamination. As mandatory public reporting and pay for performance force infection control issues to the forefront, chlorhexidine-containing products may provide a vast armamentarium for the control and prevention of HAI.
医疗保健相关感染（HAIs）会导致患者发病率增加以及医疗保健资源利用增多。尽管医疗保健技术有所进步，但HAIs的发生率仍在上升。抗菌药物有限且新药研发进展缓慢使得新型预防措施至关重要。洗必泰是一种自20世纪50年代以来就在全球使用的防腐剂溶液，是一种具有广泛抗菌活性的安全有效产品。含洗必泰产品的新用途正在得到应用，以促进防腐并预防细菌定植和感染。我们回顾了洗必泰在对抗HAIs战斗中的诸多感染控制应用，如全身皮肤清洁、皮肤去定植、术前淋浴和沐浴、血管导管部位准备、浸渍导管部位敷料、浸渍导管以及口腔去污。随着强制公开报告和按绩效付费将感染控制问题推到前沿，含洗必泰产品可能为控制和预防HAIs提供大量手段。
